Differential effects of methacholine and antigen challenge on gas exchange in allergic subjects

Reto Olgiati, Stephen Birch, Aswath Rao, Adam Wanner

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In order to better characterize the differential effects of nonspecific and specific (antigen) bronchial challenge on gas exchange, seven ragweed-sensitive subjects with a history of asthma underwent progressive inhalation challenge with methacholine and ragweed extract on two different days. For comparable severity of bronchospasm (mean specific airway conductance 0.05 sec-1cm-1H2O for methacholine and 0.06 sec-1cm-1H2O for ragweed), there was a greater decrease in mean arterial oxygen saturation after ragweed (4.7%) than after methacholine challenge (2.7%) (p < 0.05). While this was not accompanied by differences in static lung volumes, the density-dependent index decreased by 19% after ragweed (p < 0.001) but remained unchanged after methacholine challenge. These results suggest that a greater involvement of peripheral airways in the bronchospastic response is, at least in part, responsible for the greater decrease in arterial oxygen saturation after ragweed challenge.

Original languageEnglish
Pages (from-to)325-329
Number of pages5
JournalThe Journal of Allergy and Clinical Immunology
Volume67
Issue number4
DOIs
StatePublished - Jan 1 1981

Fingerprint

Ambrosia
Methacholine Chloride
Gases
Antigens
Oxygen
Bronchial Spasm
Inhalation
Asthma
Lung

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Differential effects of methacholine and antigen challenge on gas exchange in allergic subjects. / Olgiati, Reto; Birch, Stephen; Rao, Aswath; Wanner, Adam.

In: The Journal of Allergy and Clinical Immunology, Vol. 67, No. 4, 01.01.1981, p. 325-329.

Research output: Contribution to journalArticle

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