Differential effect of various doses of mestranol on the release of luteinizing hormone and follicle stimulating hormone in response to luteinizing hormone releasing hormone

D. Gonzalez-Barcena; A. J. Kastin; D. S. Schalch; C. Ponce-r; A. V. Schally

doi:10.1016/s0015-0282(16)40395-x

Differential effect of various doses of mestranol on the release of luteinizing hormone and follicle stimulating hormone in response to luteinizing hormone releasing hormone

D. Gonzalez-Barcena, A. J. Kastin, D. S. Schalch, C. Ponce-r, A. V. Schally

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Four patients with elevated plasma levels of gonadotropins were treated daily for 7 days with doses of mestranol which were increased each wk. The release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in response to the intravenous injection of 100 μg LH/RH was measured after administration of each weekly dose of estrogen. The differential release of LH and FSH after the same dose of LH/RH depended upon the dose of ingested mestranol. Mestranol seemed to affect basal values as well as response to LH/RH of FSH differently from that of LH. The results emphasize the complex interactions of LH/RH and sex steroids at the pituitary level.

Original language	English (US)
Pages (from-to)	439-442
Number of pages	4
Journal	Unknown Journal
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/s0015-0282(16)40395-x
State	Published - 1974
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/s0015-0282(16)40395-x

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Differential effect of various doses of mestranol on the release of luteinizing hormone and follicle stimulating hormone in response to luteinizing hormone releasing hormone. / Gonzalez-Barcena, D.; Kastin, A. J.; Schalch, D. S.; Ponce-r, C.; Schally, A. V.

In: Unknown Journal, Vol. 25, No. 5, 1974, p. 439-442.

Research output: Contribution to journal › Article › peer-review

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title = "Differential effect of various doses of mestranol on the release of luteinizing hormone and follicle stimulating hormone in response to luteinizing hormone releasing hormone",

abstract = "Four patients with elevated plasma levels of gonadotropins were treated daily for 7 days with doses of mestranol which were increased each wk. The release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in response to the intravenous injection of 100 μg LH/RH was measured after administration of each weekly dose of estrogen. The differential release of LH and FSH after the same dose of LH/RH depended upon the dose of ingested mestranol. Mestranol seemed to affect basal values as well as response to LH/RH of FSH differently from that of LH. The results emphasize the complex interactions of LH/RH and sex steroids at the pituitary level.",

author = "D. Gonzalez-Barcena and Kastin, {A. J.} and Schalch, {D. S.} and C. Ponce-r and Schally, {A. V.}",

note = "Funding Information: Received October 12, 1973. *Supported in part by grants from the Veterans Administration and NIH (AM-08943).",

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doi = "10.1016/s0015-0282(16)40395-x",

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AU - Gonzalez-Barcena, D.

AU - Kastin, A. J.

AU - Schalch, D. S.

AU - Ponce-r, C.

AU - Schally, A. V.

N1 - Funding Information: Received October 12, 1973. *Supported in part by grants from the Veterans Administration and NIH (AM-08943).

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N2 - Four patients with elevated plasma levels of gonadotropins were treated daily for 7 days with doses of mestranol which were increased each wk. The release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in response to the intravenous injection of 100 μg LH/RH was measured after administration of each weekly dose of estrogen. The differential release of LH and FSH after the same dose of LH/RH depended upon the dose of ingested mestranol. Mestranol seemed to affect basal values as well as response to LH/RH of FSH differently from that of LH. The results emphasize the complex interactions of LH/RH and sex steroids at the pituitary level.

AB - Four patients with elevated plasma levels of gonadotropins were treated daily for 7 days with doses of mestranol which were increased each wk. The release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in response to the intravenous injection of 100 μg LH/RH was measured after administration of each weekly dose of estrogen. The differential release of LH and FSH after the same dose of LH/RH depended upon the dose of ingested mestranol. Mestranol seemed to affect basal values as well as response to LH/RH of FSH differently from that of LH. The results emphasize the complex interactions of LH/RH and sex steroids at the pituitary level.

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Differential effect of various doses of mestranol on the release of luteinizing hormone and follicle stimulating hormone in response to luteinizing hormone releasing hormone

Abstract

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