Differential effect of allogeneic versus syngeneic mesenchymal stem cell transplantation in MRL/lpr and (NZB/NZW)F1 mice

Fei Gu, Ivan Molano, Philip Ruiz, Lingyun Sun, Gary S. Gilkeson

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

MSC are being explored as a promising novel treatment for SLE. In this study, we: 1) assessed the differential effects of allogeneic versus syngeneic MSC transplantation on lupus-like disease, 2) explored the mechanisms by which MSC modulate disease, and 3) investigated whether lupus-derived-MSC have intrinsic immunomodulatory defects. We showed that in MRL/. lpr mice and (NZB/NZW)F1 mice, both B6-MSC and lupus-MSC from young mice ameliorated SLE-like disease and reduced splenic CD3+CD4. + T lymphocytes and CD19+CD21. + B lymphocytes. However, lupus-MSC from older (NZB/NZW)F1 mice did not reduce spleen weights, glomerular IgG deposits, renal pathology, interstitial inflammation, CD3+CD4. + T lymphocytes or CD19+CD21. + B lymphocytes significantly. Thus MSC transplantation ameliorates SLE-like disease partly through decreasing CD4. + T cell and naïve mature B cell numbers. Allogeneic MSC may be preferred over syngeneic lupus-derived-MSC given the decreased overall effectiveness of post-lupus-derived-MSC, which appears partially due to disease and not exclusively intrinsic defects in the MSC themselves.

Original languageEnglish (US)
Pages (from-to)142-152
Number of pages11
JournalClinical Immunology
Volume145
Issue number2
DOIs
StatePublished - Nov 1 2012

Keywords

  • Allogeneic;
  • Mesenchymal stem cells;
  • Syngeneic
  • Systemic lupus erythematosus;

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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