DIFFERENTIAL DIAGNOSIS BETWEEN HYPOTHALAMIC AND PITUITARY hGH DEFICIENCY WITH THE AID OF SYNTHETIC GH‐RH 1–44

Z. LARON, R. KERET, B. BAUMAN, A. PERTZELAN, Z. BEN‐ZEEV, D. B. OLSEN, A. M. COMARU‐SCHALLY, A. V. SCHALLY

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Synthetic GH-RH 1-44 administered as an intravenous bolus (1 μg/kg) evoked a marked hGH rise (> 20 ng/ml) in three children with constitutional short stature and in two of eight children diagnosed as having hGH deficiency by insulin hypoglycaemia and/or clonidine tests. As judged by the intensity of the hGH response to the dose employed and the peak time, GH-RH 1-44 may be as potent as GH-RH 1-40 in children. It is concluded that GH-RH is an important addition to the endocrine armamentarium, providing the means for differentiation between hypothalamic and pituitary hGH deficiency in a simple test which is devoid of side effects.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalClinical Endocrinology
Volume21
Issue number1
DOIs
StatePublished - Jul 1984
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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