Differential diagnosis between hypothalamic and pituitary hGH deficiency with the aid of synthetic GH-RH 1-44

Z. Laron, R. Keret, B. Bauman, A. Pertzelan, Z. Ben-Zeev, D. B. Olsen, A. M. Comaru-Schally, Andrew V Schally

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Synthetic GH-RH 1-44 administered as an intravenous bolus (1 μg/kg) evoked a marked hGH rise (> 20 ng/ml) in three children with constitutional short stature and in two of eight children diagnosed as having hGH deficiency by insulin hypoglycaemia and/or clonidine tests. As judged by the intensity of the hGH response to the dose employed and the peak time, GH-RH 1-44 may be as potent as GH-RH 1-40 in children. It is concluded that GH-RH is an important addition to the endocrine armamentarium, providing the means for differentiation between hypothalamic and pituitary hGH deficiency in a simple test which is devoid of side effects.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalClinical Endocrinology
Volume21
Issue number1
StatePublished - Sep 6 1984
Externally publishedYes

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Differential Diagnosis
Clonidine
Hypoglycemia
Insulin

ASJC Scopus subject areas

  • Endocrinology

Cite this

Laron, Z., Keret, R., Bauman, B., Pertzelan, A., Ben-Zeev, Z., Olsen, D. B., ... Schally, A. V. (1984). Differential diagnosis between hypothalamic and pituitary hGH deficiency with the aid of synthetic GH-RH 1-44. Clinical Endocrinology, 21(1), 9-12.

Differential diagnosis between hypothalamic and pituitary hGH deficiency with the aid of synthetic GH-RH 1-44. / Laron, Z.; Keret, R.; Bauman, B.; Pertzelan, A.; Ben-Zeev, Z.; Olsen, D. B.; Comaru-Schally, A. M.; Schally, Andrew V.

In: Clinical Endocrinology, Vol. 21, No. 1, 06.09.1984, p. 9-12.

Research output: Contribution to journalArticle

Laron, Z, Keret, R, Bauman, B, Pertzelan, A, Ben-Zeev, Z, Olsen, DB, Comaru-Schally, AM & Schally, AV 1984, 'Differential diagnosis between hypothalamic and pituitary hGH deficiency with the aid of synthetic GH-RH 1-44', Clinical Endocrinology, vol. 21, no. 1, pp. 9-12.
Laron Z, Keret R, Bauman B, Pertzelan A, Ben-Zeev Z, Olsen DB et al. Differential diagnosis between hypothalamic and pituitary hGH deficiency with the aid of synthetic GH-RH 1-44. Clinical Endocrinology. 1984 Sep 6;21(1):9-12.
Laron, Z. ; Keret, R. ; Bauman, B. ; Pertzelan, A. ; Ben-Zeev, Z. ; Olsen, D. B. ; Comaru-Schally, A. M. ; Schally, Andrew V. / Differential diagnosis between hypothalamic and pituitary hGH deficiency with the aid of synthetic GH-RH 1-44. In: Clinical Endocrinology. 1984 ; Vol. 21, No. 1. pp. 9-12.
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