Differential deoxyadenosine toxicity to immature rabbit cartilage in vitro. a model for the chondro‐osseous dysplasia of adenosine deaminase deficiency

Robert L. Wortmann, Judith A. Veum, Lawrence M. Ryan, Herman S. Cheung

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Deoxyadenosine metabolism was investigated in rabbit growth plate and articular cartilage to elucidate the biochemical basis for the chondro-osseous dysplasia observed in adenosine deaminase (ADA) deficiency. Models of ADA deficiency, the combination of deoxyadenosine and either of 2 ADA inhibitors, were selectively toxic to immature cartilage, supporting the hypothesis that the chondro-ossoeus dysplasia of ADA deficiency is the consequence of the enzyme deficiency. Depletion of ATP may play a role in the altered chondrocyte viability and function observed in this model.

Original languageEnglish (US)
Pages (from-to)1014-1021
Number of pages8
JournalArthritis & Rheumatism
Volume32
Issue number8
DOIs
StatePublished - Aug 1989
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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