Abstract
Deoxyadenosine metabolism was investigated in rabbit growth plate and articular cartilage to elucidate the biochemical basis for the chondro-osseous dysplasia observed in adenosine deaminase (ADA) deficiency. Models of ADA deficiency, the combination of deoxyadenosine and either of 2 ADA inhibitors, were selectively toxic to immature cartilage, supporting the hypothesis that the chondro-ossoeus dysplasia of ADA deficiency is the consequence of the enzyme deficiency. Depletion of ATP may play a role in the altered chondrocyte viability and function observed in this model.
Original language | English (US) |
---|---|
Pages (from-to) | 1014-1021 |
Number of pages | 8 |
Journal | Arthritis & Rheumatism |
Volume | 32 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1989 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Rheumatology
- Immunology
- Pharmacology (medical)