Abstract
Deoxyadenosine metabolism was investigated in rabbit growth plate and articular cartilage to elucidate the biochemical basis for the chondro-osseous dysplasia observed in adenosine deaminase (ADA) deficiency. Models of ADA deficiency, the combination of deoxyadenosine and either of 2 ADA inhibitors, were selectively toxic to immature cartilage, supporting the hypothesis that the chondro-ossoeus dysplasia of ADA deficiency is the consequence of the enzyme deficiency. Depletion of ATP may play a role in the altered chondrocyte viability and function observed in this model.
| Original language | English |
|---|---|
| Pages (from-to) | 1014-1021 |
| Number of pages | 8 |
| Journal | Arthritis and Rheumatism |
| Volume | 32 |
| Issue number | 8 |
| State | Published - Jan 1 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Rheumatology
Cite this
Differential deoxyadenosine toxicity to immature rabbit cartilage in vitro. A model for the chondro-osseous dysplasia of adenosine deaminase deficiency. / Wortmann, R. L.; Veum, J. A.; Ryan, L. M.; Cheung, Herman S.
In: Arthritis and Rheumatism, Vol. 32, No. 8, 01.01.1989, p. 1014-1021.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential deoxyadenosine toxicity to immature rabbit cartilage in vitro. A model for the chondro-osseous dysplasia of adenosine deaminase deficiency
AU - Wortmann, R. L.
AU - Veum, J. A.
AU - Ryan, L. M.
AU - Cheung, Herman S
PY - 1989/1/1
Y1 - 1989/1/1
N2 - Deoxyadenosine metabolism was investigated in rabbit growth plate and articular cartilage to elucidate the biochemical basis for the chondro-osseous dysplasia observed in adenosine deaminase (ADA) deficiency. Models of ADA deficiency, the combination of deoxyadenosine and either of 2 ADA inhibitors, were selectively toxic to immature cartilage, supporting the hypothesis that the chondro-ossoeus dysplasia of ADA deficiency is the consequence of the enzyme deficiency. Depletion of ATP may play a role in the altered chondrocyte viability and function observed in this model.
AB - Deoxyadenosine metabolism was investigated in rabbit growth plate and articular cartilage to elucidate the biochemical basis for the chondro-osseous dysplasia observed in adenosine deaminase (ADA) deficiency. Models of ADA deficiency, the combination of deoxyadenosine and either of 2 ADA inhibitors, were selectively toxic to immature cartilage, supporting the hypothesis that the chondro-ossoeus dysplasia of ADA deficiency is the consequence of the enzyme deficiency. Depletion of ATP may play a role in the altered chondrocyte viability and function observed in this model.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024450234&partnerID=8YFLogxK
M3 - Article
C2 - 2788422
AN - SCOPUS:0024450234
VL - 32
SP - 1014
EP - 1021
JO - Arthritis and Rheumatology
JF - Arthritis and Rheumatology
SN - 2326-5191
IS - 8
ER -