Differential deoxyadenosine toxicity to immature rabbit cartilage in vitro. A model for the chondro-osseous dysplasia of adenosine deaminase deficiency

R. L. Wortmann, J. A. Veum, L. M. Ryan, Herman S Cheung

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Deoxyadenosine metabolism was investigated in rabbit growth plate and articular cartilage to elucidate the biochemical basis for the chondro-osseous dysplasia observed in adenosine deaminase (ADA) deficiency. Models of ADA deficiency, the combination of deoxyadenosine and either of 2 ADA inhibitors, were selectively toxic to immature cartilage, supporting the hypothesis that the chondro-ossoeus dysplasia of ADA deficiency is the consequence of the enzyme deficiency. Depletion of ATP may play a role in the altered chondrocyte viability and function observed in this model.

Original languageEnglish
Pages (from-to)1014-1021
Number of pages8
JournalArthritis and Rheumatism
Volume32
Issue number8
StatePublished - Jan 1 1989
Externally publishedYes

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Cartilage
Rabbits
Adenosine Deaminase Inhibitors
Growth Plate
Poisons
Articular Cartilage
Chondrocytes
Adenosine Triphosphate
Enzymes
Severe combined immunodeficiency due to adenosine deaminase deficiency
In Vitro Techniques
2'-deoxyadenosine

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

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Differential deoxyadenosine toxicity to immature rabbit cartilage in vitro. A model for the chondro-osseous dysplasia of adenosine deaminase deficiency. / Wortmann, R. L.; Veum, J. A.; Ryan, L. M.; Cheung, Herman S.

In: Arthritis and Rheumatism, Vol. 32, No. 8, 01.01.1989, p. 1014-1021.

Research output: Contribution to journalArticle

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