Abstract
Deoxyadenosine metabolism was investigated in rabbit growth plate and articular cartilage to elucidate the biochemical basis for the chondro-osseous dysplasia observed in adenosine deaminase (ADA) deficiency. Models of ADA deficiency, the combination of deoxyadenosine and either of 2 ADA inhibitors, were selectively toxic to immature cartilage, supporting the hypothesis that the chondro-ossoeus dysplasia of ADA deficiency is the consequence of the enzyme deficiency. Depletion of ATP may play a role in the altered chondrocyte viability and function observed in this model.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1014-1021 |
| Number of pages | 8 |
| Journal | Arthritis & Rheumatism |
| Volume | 32 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1989 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Rheumatology
- Immunology
- Pharmacology (medical)
Fingerprint Dive into the research topics of 'Differential deoxyadenosine toxicity to immature rabbit cartilage in vitro. a model for the chondro‐osseous dysplasia of adenosine deaminase deficiency'. Together they form a unique fingerprint.
Cite this
Wortmann, R. L., Veum, J. A., Ryan, L. M., & Cheung, H. S. (1989). Differential deoxyadenosine toxicity to immature rabbit cartilage in vitro. a model for the chondro‐osseous dysplasia of adenosine deaminase deficiency. Arthritis & Rheumatism, 32(8), 1014-1021. https://doi.org/10.1002/anr.1780320811