Differential cholinergic innervation within functional subdivisions of the human cerebral cortex: A choline acetyltransferase study

M. ‐Marsel Mesulam, Louis B. Hersh, Deborah C. Mash, Changiz Geula

Research output: Contribution to journalArticlepeer-review

144 Scopus citations

Abstract

The distribution of cholinergic fibers in the human brain was investigated with choline acetyltransferase immunocytochemistry in 35 cytoarchitectonic subdivisions of the cerebral cortex. All cortical areas and all cell layers contained cholinergic axons. These fibers displayed numerous varicosities and, on occasion, complex preterminal profiles arranged in the form of dense clusters. The density of cholinergic axons tended to be higher in the more superficial layers of the cerebral cortex. Several distinct patterns of lamination were identified. There were also major differences in the overall density of cholinergic axons from one cytoarchitectonic area to another. The cholinergic innervation of primary sensory, unimodal, and heteromodal association areas was lighter than that of paralimbic and limbic areas. Within unimodal association areas, the density of cholinergic axons and varicosities was significantly lower in the upstream (parasensory) sectors than in the downstream sectors. Within paralimbic regions, the non- isocortical sectors had a higher density of cholinergic innervation than the isocortical sectors. The highest density of cholinergic axons was encountered in core limbic structures such as the hippocampus and amygdala. These observations show that the cholinergic innervation of the human cerebral cortex displays regional variations that closely follow the organization of information processing systems.

Original languageEnglish (US)
Pages (from-to)316-328
Number of pages13
JournalJournal of Comparative Neurology
Volume318
Issue number3
DOIs
StatePublished - Apr 15 1992
Externally publishedYes

Keywords

  • cerebral cortex
  • cholinergic fibers
  • human brain

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Differential cholinergic innervation within functional subdivisions of the human cerebral cortex: A choline acetyltransferase study'. Together they form a unique fingerprint.

Cite this