Differences in the frequency of resistance to antiretroviral drug classes among human immunodeficiency virus type 1 clinical isolates

Rafael E Campo, Paola Lichtenberger, Isabella Rosa-Cunha, German Suarez, Fernando A. Rivera, Allan E Rodriguez, Dushyantha T Jayaweera, Natalie A. Wahlay, Michael A Kolber

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Genotypic resistance to all antiretroviral classes was widespread among human immunodeficiency virus type 1 isolates failing therapy. Resistance to nonnucleoside reverse transcriptase inhibitors was found most frequently and resistance to protease inhibitors was found least frequently, most likely due to differences in the number of enzymatic amino acid substitutions leading to resistance to each particular drug class.

Original languageEnglish
Pages (from-to)3376-3378
Number of pages3
JournalJournal of Clinical Microbiology
Volume41
Issue number7
DOIs
StatePublished - Jul 1 2003

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Reverse Transcriptase Inhibitors
Amino Acid Substitution
Protease Inhibitors
HIV-1
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

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AU - Campo, Rafael E

AU - Lichtenberger, Paola

AU - Rosa-Cunha, Isabella

AU - Suarez, German

AU - Rivera, Fernando A.

AU - Rodriguez, Allan E

AU - Jayaweera, Dushyantha T

AU - Wahlay, Natalie A.

AU - Kolber, Michael A

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AB - Genotypic resistance to all antiretroviral classes was widespread among human immunodeficiency virus type 1 isolates failing therapy. Resistance to nonnucleoside reverse transcriptase inhibitors was found most frequently and resistance to protease inhibitors was found least frequently, most likely due to differences in the number of enzymatic amino acid substitutions leading to resistance to each particular drug class.

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