Differences in T cell subsets between men and women with idiopathic thrombocytopenic purpura

R. Mylvaganam, Y. S. Ahn, W. J. Harrington, C. I. Kim, H. G. Gratzner

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder, occurring predominantly in women. We studied by flow cytofluorimetry the T cell subsets in men and women with ITP and compared them with healthy sex-matched volunteers. In healthy controls, women were found to have higher proportions of T helper/inducer (T(h/i)) and lower T suppressor/cytotoxic (T(s/c)) lymphocytes and consequently higher T(h/i):T(s/c) ratios than men. Accordingly, in clinical surveys, patients and controls should be matched for sex for proper comparisons. In patients with ITP in its active phase, an imbalance in T cell subsets was found in both sexes. The perturbation was more severe in women who had a marked decrease in number and proportion of T(h/i) lymphocytes and an increase in the proportion of T(s/c) lymphocytes, whereas in men only, the proportion of T(h/i) lymphocytes was decreased. When patients with active disease were compared to those with ITP in remission, the decrease in T(h/i) subsets still persisted in both sexes but the T(s/c) subset in women had returned to normal proportions. Therefore, the immune imbalance in ITP is more marked in women than men; imbalances in both T(h/i) and T(s/c) are present in women while T(s/c) appears not to be involved in men.

Original languageEnglish (US)
Pages (from-to)967-972
Number of pages6
JournalBlood
Volume66
Issue number4
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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