Differences in T cell subsets between men and women with idiopathic thrombocytopenic purpura

R. Mylvaganam, Yeon Ahn, W. J. Harrington, C. I. Kim, H. G. Gratzner

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Abstract

Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder, occurring predominantly in women. We studied by flow cytofluorimetry the T cell subsets in men and women with ITP and compared them with healthy sex-matched volunteers. In healthy controls, women were found to have higher proportions of T helper/inducer (T(h/i)) and lower T suppressor/cytotoxic (T(s/c)) lymphocytes and consequently higher T(h/i):T(s/c) ratios than men. Accordingly, in clinical surveys, patients and controls should be matched for sex for proper comparisons. In patients with ITP in its active phase, an imbalance in T cell subsets was found in both sexes. The perturbation was more severe in women who had a marked decrease in number and proportion of T(h/i) lymphocytes and an increase in the proportion of T(s/c) lymphocytes, whereas in men only, the proportion of T(h/i) lymphocytes was decreased. When patients with active disease were compared to those with ITP in remission, the decrease in T(h/i) subsets still persisted in both sexes but the T(s/c) subset in women had returned to normal proportions. Therefore, the immune imbalance in ITP is more marked in women than men; imbalances in both T(h/i) and T(s/c) are present in women while T(s/c) appears not to be involved in men.

Original languageEnglish
Pages (from-to)967-972
Number of pages6
JournalBlood
Volume66
Issue number4
StatePublished - Dec 11 1985

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Idiopathic Thrombocytopenic Purpura
T-cells
T-Lymphocyte Subsets
Lymphocytes
Cytotoxic T-Lymphocytes
Helper-Inducer T-Lymphocytes
Volunteers

ASJC Scopus subject areas

  • Hematology

Cite this

Mylvaganam, R., Ahn, Y., Harrington, W. J., Kim, C. I., & Gratzner, H. G. (1985). Differences in T cell subsets between men and women with idiopathic thrombocytopenic purpura. Blood, 66(4), 967-972.

Differences in T cell subsets between men and women with idiopathic thrombocytopenic purpura. / Mylvaganam, R.; Ahn, Yeon; Harrington, W. J.; Kim, C. I.; Gratzner, H. G.

In: Blood, Vol. 66, No. 4, 11.12.1985, p. 967-972.

Research output: Contribution to journalArticle

Mylvaganam, R, Ahn, Y, Harrington, WJ, Kim, CI & Gratzner, HG 1985, 'Differences in T cell subsets between men and women with idiopathic thrombocytopenic purpura', Blood, vol. 66, no. 4, pp. 967-972.
Mylvaganam R, Ahn Y, Harrington WJ, Kim CI, Gratzner HG. Differences in T cell subsets between men and women with idiopathic thrombocytopenic purpura. Blood. 1985 Dec 11;66(4):967-972.
Mylvaganam, R. ; Ahn, Yeon ; Harrington, W. J. ; Kim, C. I. ; Gratzner, H. G. / Differences in T cell subsets between men and women with idiopathic thrombocytopenic purpura. In: Blood. 1985 ; Vol. 66, No. 4. pp. 967-972.
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