Differences in neural response to extinction recall in young adults with or without history of behavioral inhibition

Tomer Shechner, Nathan A. Fox, Jamie A. Mash, Johanna M. Jarcho, Gang Chen, Ellen Leibenluft, Daniel S. Pine, Jennifer C Britton

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Behavioral inhibition (BI) is a temperament identified in early childhood that is associated with risk for anxiety disorders, yet only about half of behaviorally inhibited children manifest anxiety later in life. We compared brain function and behavior during extinction recall in a sample of nonanxious young adults characterized in childhood with BI (n = 22) or with no BI (n = 28). Three weeks after undergoing fear conditioning and extinction, participants completed a functional magnetic resonance imaging extinction recall task assessing memory and threat differentiation for conditioned stimuli. While self-report and psychophysiological measures of differential conditioning and extinction were similar across groups, BI-related differences in brain function emerged during extinction recall. Childhood BI was associated with greater activation in subgenual anterior cingulate cortex in response to cues signaling safety. This pattern of results may reflect neural correlates that promote resilience against anxiety in a temperamentally at-risk population.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalDevelopment and Psychopathology
DOIs
StateAccepted/In press - May 23 2017

Fingerprint

Young Adult
Anxiety
Temperament
Gyrus Cinguli
Brain
Anxiety Disorders
Self Report
Fear
Cues
Magnetic Resonance Imaging
Inhibition (Psychology)
Psychological Extinction
Safety
Conditioning (Psychology)

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Differences in neural response to extinction recall in young adults with or without history of behavioral inhibition. / Shechner, Tomer; Fox, Nathan A.; Mash, Jamie A.; Jarcho, Johanna M.; Chen, Gang; Leibenluft, Ellen; Pine, Daniel S.; Britton, Jennifer C.

In: Development and Psychopathology, 23.05.2017, p. 1-11.

Research output: Contribution to journalArticle

Shechner, Tomer ; Fox, Nathan A. ; Mash, Jamie A. ; Jarcho, Johanna M. ; Chen, Gang ; Leibenluft, Ellen ; Pine, Daniel S. ; Britton, Jennifer C. / Differences in neural response to extinction recall in young adults with or without history of behavioral inhibition. In: Development and Psychopathology. 2017 ; pp. 1-11.
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