Differences in lipid profiles in two Hispanic ischemic stroke populations

A. Arauz, Jose G Romano, A. Ruiz-Franco, T. Shang, Chuanhui Dong, Tatjana Rundek, Sebastian Koch, B. Hernández-Curiel, J. Pacheco, P. Rojas, F. Ruiz-Navarro, M. Katsnelson, Ralph L Sacco

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and Purpose: The study aims to compare lipid profiles among ischemic stroke patients in a predominantly Caribbean-Hispanic population in Miami and a Mestizo Hispanic population in Mexico City. Methods: We analyzed ischemic stroke Hispanic patients with complete baseline fasting lipid profile enrolled contemporaneously in the prospective registries of two tertiary care teaching hospitals in Mexico City and Miami. Demographic characteristics, risk factors, medications, ischemic stroke subtype, and first fasting lipid profile were compared. Vascular risk factor definitions were standardized. Multiple linear regression analysis was performed to compare lipid fractions. Results: A total of 324 patients from Mexico and 236 from Miami were analyzed. Mexicans were significantly younger (58·1 vs. 67·4 years), had a lower frequency of hypertension (53·4% vs. 79·7%), and lower body mass index (27 vs. 28·5). There was a trend toward greater prevalence of diabetes in Mexicans (31·5 vs. 24·6%, P=0·07). Statin use at the time of ischemic stroke was more common in Miami Hispanics (18·6 vs. 9·4%). Mexicans had lower total cholesterol levels (169·9±46·1 vs. 179·9±48·4mg/dl), lower low-density lipoprotein (92·3±37·1 vs. 108·2±40·8mg/dl), and higher triglyceride levels (166·9±123·9 vs. 149·2±115·2mg/dl). These differences remained significant after adjusting for age, gender, hypertension, diabetes, body mass index, smoking, ischemic stroke subtype, and statin use. Conclusion: We found significant differences in lipid fractions in Hispanic ischemic stroke patients, with lower total cholesterol and low-density lipoprotein, and higher triglyceride levels in Mexicans. These findings highlight the heterogeneity of dyslipidemia among the Hispanic race-ethnic group and may lead to different secondary prevention strategies.

Original languageEnglish
Pages (from-to)394-399
Number of pages6
JournalInternational Journal of Stroke
Volume9
Issue number4
DOIs
StatePublished - Jan 1 2014

Fingerprint

Hispanic Americans
Stroke
Lipids
Mexico
Population
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Fasting
Body Mass Index
Cholesterol
Hypertension
Tertiary Healthcare
Dyslipidemias
Secondary Prevention
LDL Lipoproteins
Ethnic Groups
Teaching Hospitals
Registries
Linear Models
Triglycerides
Smoking

Keywords

  • Cholesterol
  • Hispanics
  • Ischemic stroke

ASJC Scopus subject areas

  • Neurology

Cite this

Differences in lipid profiles in two Hispanic ischemic stroke populations. / Arauz, A.; Romano, Jose G; Ruiz-Franco, A.; Shang, T.; Dong, Chuanhui; Rundek, Tatjana; Koch, Sebastian; Hernández-Curiel, B.; Pacheco, J.; Rojas, P.; Ruiz-Navarro, F.; Katsnelson, M.; Sacco, Ralph L.

In: International Journal of Stroke, Vol. 9, No. 4, 01.01.2014, p. 394-399.

Research output: Contribution to journalArticle

Arauz, A, Romano, JG, Ruiz-Franco, A, Shang, T, Dong, C, Rundek, T, Koch, S, Hernández-Curiel, B, Pacheco, J, Rojas, P, Ruiz-Navarro, F, Katsnelson, M & Sacco, RL 2014, 'Differences in lipid profiles in two Hispanic ischemic stroke populations', International Journal of Stroke, vol. 9, no. 4, pp. 394-399. https://doi.org/10.1111/ijs.12239
Arauz, A. ; Romano, Jose G ; Ruiz-Franco, A. ; Shang, T. ; Dong, Chuanhui ; Rundek, Tatjana ; Koch, Sebastian ; Hernández-Curiel, B. ; Pacheco, J. ; Rojas, P. ; Ruiz-Navarro, F. ; Katsnelson, M. ; Sacco, Ralph L. / Differences in lipid profiles in two Hispanic ischemic stroke populations. In: International Journal of Stroke. 2014 ; Vol. 9, No. 4. pp. 394-399.
@article{f98bbc68156042bb85686a3102d11d35,
title = "Differences in lipid profiles in two Hispanic ischemic stroke populations",
abstract = "Background and Purpose: The study aims to compare lipid profiles among ischemic stroke patients in a predominantly Caribbean-Hispanic population in Miami and a Mestizo Hispanic population in Mexico City. Methods: We analyzed ischemic stroke Hispanic patients with complete baseline fasting lipid profile enrolled contemporaneously in the prospective registries of two tertiary care teaching hospitals in Mexico City and Miami. Demographic characteristics, risk factors, medications, ischemic stroke subtype, and first fasting lipid profile were compared. Vascular risk factor definitions were standardized. Multiple linear regression analysis was performed to compare lipid fractions. Results: A total of 324 patients from Mexico and 236 from Miami were analyzed. Mexicans were significantly younger (58·1 vs. 67·4 years), had a lower frequency of hypertension (53·4{\%} vs. 79·7{\%}), and lower body mass index (27 vs. 28·5). There was a trend toward greater prevalence of diabetes in Mexicans (31·5 vs. 24·6{\%}, P=0·07). Statin use at the time of ischemic stroke was more common in Miami Hispanics (18·6 vs. 9·4{\%}). Mexicans had lower total cholesterol levels (169·9±46·1 vs. 179·9±48·4mg/dl), lower low-density lipoprotein (92·3±37·1 vs. 108·2±40·8mg/dl), and higher triglyceride levels (166·9±123·9 vs. 149·2±115·2mg/dl). These differences remained significant after adjusting for age, gender, hypertension, diabetes, body mass index, smoking, ischemic stroke subtype, and statin use. Conclusion: We found significant differences in lipid fractions in Hispanic ischemic stroke patients, with lower total cholesterol and low-density lipoprotein, and higher triglyceride levels in Mexicans. These findings highlight the heterogeneity of dyslipidemia among the Hispanic race-ethnic group and may lead to different secondary prevention strategies.",
keywords = "Cholesterol, Hispanics, Ischemic stroke",
author = "A. Arauz and Romano, {Jose G} and A. Ruiz-Franco and T. Shang and Chuanhui Dong and Tatjana Rundek and Sebastian Koch and B. Hern{\'a}ndez-Curiel and J. Pacheco and P. Rojas and F. Ruiz-Navarro and M. Katsnelson and Sacco, {Ralph L}",
year = "2014",
month = "1",
day = "1",
doi = "10.1111/ijs.12239",
language = "English",
volume = "9",
pages = "394--399",
journal = "International Journal of Stroke",
issn = "1747-4930",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Differences in lipid profiles in two Hispanic ischemic stroke populations

AU - Arauz, A.

AU - Romano, Jose G

AU - Ruiz-Franco, A.

AU - Shang, T.

AU - Dong, Chuanhui

AU - Rundek, Tatjana

AU - Koch, Sebastian

AU - Hernández-Curiel, B.

AU - Pacheco, J.

AU - Rojas, P.

AU - Ruiz-Navarro, F.

AU - Katsnelson, M.

AU - Sacco, Ralph L

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background and Purpose: The study aims to compare lipid profiles among ischemic stroke patients in a predominantly Caribbean-Hispanic population in Miami and a Mestizo Hispanic population in Mexico City. Methods: We analyzed ischemic stroke Hispanic patients with complete baseline fasting lipid profile enrolled contemporaneously in the prospective registries of two tertiary care teaching hospitals in Mexico City and Miami. Demographic characteristics, risk factors, medications, ischemic stroke subtype, and first fasting lipid profile were compared. Vascular risk factor definitions were standardized. Multiple linear regression analysis was performed to compare lipid fractions. Results: A total of 324 patients from Mexico and 236 from Miami were analyzed. Mexicans were significantly younger (58·1 vs. 67·4 years), had a lower frequency of hypertension (53·4% vs. 79·7%), and lower body mass index (27 vs. 28·5). There was a trend toward greater prevalence of diabetes in Mexicans (31·5 vs. 24·6%, P=0·07). Statin use at the time of ischemic stroke was more common in Miami Hispanics (18·6 vs. 9·4%). Mexicans had lower total cholesterol levels (169·9±46·1 vs. 179·9±48·4mg/dl), lower low-density lipoprotein (92·3±37·1 vs. 108·2±40·8mg/dl), and higher triglyceride levels (166·9±123·9 vs. 149·2±115·2mg/dl). These differences remained significant after adjusting for age, gender, hypertension, diabetes, body mass index, smoking, ischemic stroke subtype, and statin use. Conclusion: We found significant differences in lipid fractions in Hispanic ischemic stroke patients, with lower total cholesterol and low-density lipoprotein, and higher triglyceride levels in Mexicans. These findings highlight the heterogeneity of dyslipidemia among the Hispanic race-ethnic group and may lead to different secondary prevention strategies.

AB - Background and Purpose: The study aims to compare lipid profiles among ischemic stroke patients in a predominantly Caribbean-Hispanic population in Miami and a Mestizo Hispanic population in Mexico City. Methods: We analyzed ischemic stroke Hispanic patients with complete baseline fasting lipid profile enrolled contemporaneously in the prospective registries of two tertiary care teaching hospitals in Mexico City and Miami. Demographic characteristics, risk factors, medications, ischemic stroke subtype, and first fasting lipid profile were compared. Vascular risk factor definitions were standardized. Multiple linear regression analysis was performed to compare lipid fractions. Results: A total of 324 patients from Mexico and 236 from Miami were analyzed. Mexicans were significantly younger (58·1 vs. 67·4 years), had a lower frequency of hypertension (53·4% vs. 79·7%), and lower body mass index (27 vs. 28·5). There was a trend toward greater prevalence of diabetes in Mexicans (31·5 vs. 24·6%, P=0·07). Statin use at the time of ischemic stroke was more common in Miami Hispanics (18·6 vs. 9·4%). Mexicans had lower total cholesterol levels (169·9±46·1 vs. 179·9±48·4mg/dl), lower low-density lipoprotein (92·3±37·1 vs. 108·2±40·8mg/dl), and higher triglyceride levels (166·9±123·9 vs. 149·2±115·2mg/dl). These differences remained significant after adjusting for age, gender, hypertension, diabetes, body mass index, smoking, ischemic stroke subtype, and statin use. Conclusion: We found significant differences in lipid fractions in Hispanic ischemic stroke patients, with lower total cholesterol and low-density lipoprotein, and higher triglyceride levels in Mexicans. These findings highlight the heterogeneity of dyslipidemia among the Hispanic race-ethnic group and may lead to different secondary prevention strategies.

KW - Cholesterol

KW - Hispanics

KW - Ischemic stroke

UR - http://www.scopus.com/inward/record.url?scp=84899990008&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899990008&partnerID=8YFLogxK

U2 - 10.1111/ijs.12239

DO - 10.1111/ijs.12239

M3 - Article

C2 - 24898282

AN - SCOPUS:84899990008

VL - 9

SP - 394

EP - 399

JO - International Journal of Stroke

JF - International Journal of Stroke

SN - 1747-4930

IS - 4

ER -