Differences in CSF concentrations of thyrotropin-releasing hormone in depressed patients and normal subjects: Negative findings

Alec Roy, Owen M. Wolkowitz, Garth Bissette, Charles Nemeroff

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Since there have been reports of elevated CSF concentrations of thyrotropin-releasing hormone (TRH) in depression, the authors compared the TRH levels of 17 depressed patients and 19 normal subjects. All subjects underwent lumbar punctures after fasting overnight, and CSF concentrations of TRH were determined by radioimmunoassay. CSF concentrations of norepinephrine and monoamine metabolites were also measured. There was no significant difference between the two groups on any measure, and in the depressed patients there was no significant relation between CSF concentrations of TRH and thyrotropin-stimulating hormone responses to TRH infusion.

Original languageEnglish
Pages (from-to)600-602
Number of pages3
JournalAmerican Journal of Psychiatry
Volume151
Issue number4
StatePublished - Apr 1 1994
Externally publishedYes

Fingerprint

Thyrotropin-Releasing Hormone
Spinal Puncture
Thyrotropin
Radioimmunoassay
Fasting
Norepinephrine
Hormones
Depression

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Differences in CSF concentrations of thyrotropin-releasing hormone in depressed patients and normal subjects : Negative findings. / Roy, Alec; Wolkowitz, Owen M.; Bissette, Garth; Nemeroff, Charles.

In: American Journal of Psychiatry, Vol. 151, No. 4, 01.04.1994, p. 600-602.

Research output: Contribution to journalArticle

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