TY - JOUR
T1 - Differences in CSF concentrations of thyrotropin-releasing hormone in depressed patients and normal subjects
T2 - Negative findings
AU - Roy, Alec
AU - Wolkowitz, Owen M.
AU - Bissette, Garth
AU - Nemeroff, Charles B.
PY - 1994/4
Y1 - 1994/4
N2 - Since there have been reports of elevated CSF concentrations of thyrotropin-releasing hormone (TRH) in depression, the authors compared the TRH levels of 17 depressed patients and 19 normal subjects. All subjects underwent lumbar punctures after fasting overnight, and CSF concentrations of TRH were determined by radioimmunoassay. CSF concentrations of norepinephrine and monoamine metabolites were also measured. There was no significant difference between the two groups on any measure, and in the depressed patients there was no significant relation between CSF concentrations of TRH and thyrotropin-stimulating hormone responses to TRH infusion.
AB - Since there have been reports of elevated CSF concentrations of thyrotropin-releasing hormone (TRH) in depression, the authors compared the TRH levels of 17 depressed patients and 19 normal subjects. All subjects underwent lumbar punctures after fasting overnight, and CSF concentrations of TRH were determined by radioimmunoassay. CSF concentrations of norepinephrine and monoamine metabolites were also measured. There was no significant difference between the two groups on any measure, and in the depressed patients there was no significant relation between CSF concentrations of TRH and thyrotropin-stimulating hormone responses to TRH infusion.
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U2 - 10.1176/ajp.151.4.600
DO - 10.1176/ajp.151.4.600
M3 - Article
C2 - 7511876
AN - SCOPUS:0028351130
VL - 151
SP - 600
EP - 602
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
SN - 0002-953X
IS - 4
ER -
