Abstract
Since there have been reports of elevated CSF concentrations of thyrotropin-releasing hormone (TRH) in depression, the authors compared the TRH levels of 17 depressed patients and 19 normal subjects. All subjects underwent lumbar punctures after fasting overnight, and CSF concentrations of TRH were determined by radioimmunoassay. CSF concentrations of norepinephrine and monoamine metabolites were also measured. There was no significant difference between the two groups on any measure, and in the depressed patients there was no significant relation between CSF concentrations of TRH and thyrotropin-stimulating hormone responses to TRH infusion.
| Original language | English |
|---|---|
| Pages (from-to) | 600-602 |
| Number of pages | 3 |
| Journal | American Journal of Psychiatry |
| Volume | 151 |
| Issue number | 4 |
| State | Published - Apr 1 1994 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
Differences in CSF concentrations of thyrotropin-releasing hormone in depressed patients and normal subjects : Negative findings. / Roy, Alec; Wolkowitz, Owen M.; Bissette, Garth; Nemeroff, Charles.
In: American Journal of Psychiatry, Vol. 151, No. 4, 01.04.1994, p. 600-602.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differences in CSF concentrations of thyrotropin-releasing hormone in depressed patients and normal subjects
T2 - Negative findings
AU - Roy, Alec
AU - Wolkowitz, Owen M.
AU - Bissette, Garth
AU - Nemeroff, Charles
PY - 1994/4/1
Y1 - 1994/4/1
N2 - Since there have been reports of elevated CSF concentrations of thyrotropin-releasing hormone (TRH) in depression, the authors compared the TRH levels of 17 depressed patients and 19 normal subjects. All subjects underwent lumbar punctures after fasting overnight, and CSF concentrations of TRH were determined by radioimmunoassay. CSF concentrations of norepinephrine and monoamine metabolites were also measured. There was no significant difference between the two groups on any measure, and in the depressed patients there was no significant relation between CSF concentrations of TRH and thyrotropin-stimulating hormone responses to TRH infusion.
AB - Since there have been reports of elevated CSF concentrations of thyrotropin-releasing hormone (TRH) in depression, the authors compared the TRH levels of 17 depressed patients and 19 normal subjects. All subjects underwent lumbar punctures after fasting overnight, and CSF concentrations of TRH were determined by radioimmunoassay. CSF concentrations of norepinephrine and monoamine metabolites were also measured. There was no significant difference between the two groups on any measure, and in the depressed patients there was no significant relation between CSF concentrations of TRH and thyrotropin-stimulating hormone responses to TRH infusion.
UR - http://www.scopus.com/inward/record.url?scp=0028351130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028351130&partnerID=8YFLogxK
M3 - Article
VL - 151
SP - 600
EP - 602
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
SN - 0002-953X
IS - 4
ER -