Differences in CSF concentrations of thyrotropin-releasing hormone in depressed patients and normal subjects: Negative findings

Alec Roy, Owen M. Wolkowitz, Garth Bissette, Charles B. Nemeroff

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Since there have been reports of elevated CSF concentrations of thyrotropin-releasing hormone (TRH) in depression, the authors compared the TRH levels of 17 depressed patients and 19 normal subjects. All subjects underwent lumbar punctures after fasting overnight, and CSF concentrations of TRH were determined by radioimmunoassay. CSF concentrations of norepinephrine and monoamine metabolites were also measured. There was no significant difference between the two groups on any measure, and in the depressed patients there was no significant relation between CSF concentrations of TRH and thyrotropin-stimulating hormone responses to TRH infusion.

Original languageEnglish (US)
Pages (from-to)600-602
Number of pages3
JournalAmerican Journal of Psychiatry
Volume151
Issue number4
DOIs
StatePublished - Apr 1994
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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