We have previously demonstrated that treatment with CTX, VP-16, or the combination of CTX + ADM leads to complete body alopecia in the 7 to 11 day old rat model. The present study was designed to compare the pattern of chemotherapy-induced alopecia between the 7, 14 and 21 day old rat. Two separate experiments were carried out as follows : Eighteen rats, six-7 days old, six-14 days old, and six-21 days old, received CTX 35 mg/kg I.P. as a single dose. Alopecia was recorded 10 days later. The 7-day old rats became totally alopec ic. In contrast, in the 14-day old rats, the head was protected while the body became alopécie. No alopecia was produced in the 21 day old rats. In a separate experiment, twenty four rats, eight-7 days old, eight-14 days old and eight-21 days old, received VP-16 1,5 mg/kg I.P. for three consecutive days. Alopecia was recorded 10 days later. The 7-day old rats became totally alopécie. In the 14 day-old rats, the head was protected but the body became alopécie. No alopecia was observed in the 21 day-old rats. In other experiments using the combination of CTX + ADM, similar result-s were obtained. We conclude that future correlative biochemical and cyCo logical studies on hair follicles Irurn the young rat model may reveal significant insight into the mechanism of chemotherapy-induced alopecia.
|Original language||English (US)|
|Journal||Journal of Investigative Medicine|
|State||Published - Jan 1 1996|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)