Differences in chemotherapy-induced alopecia pattern with rat age

J. J. Jtmenez, B. J. Herskowitz, E. E. Perez-Roura, A. A. Yunis

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Abstract

We have previously demonstrated that treatment with CTX, VP-16, or the combination of CTX + ADM leads to complete body alopecia in the 7 to 11 day old rat model. The present study was designed to compare the pattern of chemotherapy-induced alopecia between the 7, 14 and 21 day old rat. Two separate experiments were carried out as follows : Eighteen rats, six-7 days old, six-14 days old, and six-21 days old, received CTX 35 mg/kg I.P. as a single dose. Alopecia was recorded 10 days later. The 7-day old rats became totally alopec ic. In contrast, in the 14-day old rats, the head was protected while the body became alopécie. No alopecia was produced in the 21 day old rats. In a separate experiment, twenty four rats, eight-7 days old, eight-14 days old and eight-21 days old, received VP-16 1,5 mg/kg I.P. for three consecutive days. Alopecia was recorded 10 days later. The 7-day old rats became totally alopécie. In the 14 day-old rats, the head was protected but the body became alopécie. No alopecia was observed in the 21 day-old rats. In other experiments using the combination of CTX + ADM, similar result-s were obtained. We conclude that future correlative biochemical and cyCo logical studies on hair follicles Irurn the young rat model may reveal significant insight into the mechanism of chemotherapy-induced alopecia.

Original languageEnglish (US)
Pages (from-to)249a
JournalJournal of Investigative Medicine
Volume44
Issue number3
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Jtmenez, J. J., Herskowitz, B. J., Perez-Roura, E. E., & Yunis, A. A. (1996). Differences in chemotherapy-induced alopecia pattern with rat age. Journal of Investigative Medicine, 44(3), 249a.