Differences in Cellular Uptake and Cytofluorescence of Adriamycin and N-Trifluoroacetyladriamycin-14-valerate

Awtar Krishan, Mervyn Israel, Edward J. Modest, Emil Frei

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Adriamycin specific fluorescence appears slowly in living cells and is localized in nuclei and chromosomes. N Trifluoroacetyladriamycin 14 valerate, a recently synthesized adriamycin analog, differs from the parent anthracycline in the rapid appearance of its fluorescence in the cytoplasm of living cells and the lack of any fluorescent binding to nuclei and chromosomes.

Original languageEnglish (US)
Pages (from-to)2108-2110
Number of pages3
JournalCancer Research
Volume36
Issue number6
StatePublished - Jun 1976

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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