Differences in cellular uptake and cytofluorescence of adriamycin and N trifluoroacetyladriamycin 14 valerate

A. Krishan, M. Israel, E. J. Modest, E. Frei

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Adriamycin specific fluorescence appears slowly in living cells and is localized in nuclei and chromosomes. N Trifluoroacetyladriamycin 14 valerate, a recently synthesized adriamycin analog, differs from the parent anthracycline in the rapid appearance of its fluorescence in the cytoplasm of living cells and the lack of any fluorescent binding to nuclei and chromosomes.

Original languageEnglish
Pages (from-to)2108-2110
Number of pages3
JournalCancer Research
Volume36
Issue number6
StatePublished - Dec 1 1976
Externally publishedYes

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valrubicin
Doxorubicin
Chromosomes
Fluorescence
Anthracyclines
Cytoplasm

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Differences in cellular uptake and cytofluorescence of adriamycin and N trifluoroacetyladriamycin 14 valerate. / Krishan, A.; Israel, M.; Modest, E. J.; Frei, E.

In: Cancer Research, Vol. 36, No. 6, 01.12.1976, p. 2108-2110.

Research output: Contribution to journalArticle

Krishan, A, Israel, M, Modest, EJ & Frei, E 1976, 'Differences in cellular uptake and cytofluorescence of adriamycin and N trifluoroacetyladriamycin 14 valerate', Cancer Research, vol. 36, no. 6, pp. 2108-2110.
Krishan, A. ; Israel, M. ; Modest, E. J. ; Frei, E. / Differences in cellular uptake and cytofluorescence of adriamycin and N trifluoroacetyladriamycin 14 valerate. In: Cancer Research. 1976 ; Vol. 36, No. 6. pp. 2108-2110.
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