Differences in antibody response to streptococcal antigens in children with rheumatic and non rheumatic mitral valve disease

S. T. Shulman, E. M. Ayoub, B. E. Victorica, I. H. Gessner, D. F. Tamer, F. A. Hernandez

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The usefulness of streptococcal antibody tests, anti streptolysin O (ASO), antidesoxyribonuclease B (anti DNAse B), and anti group A carbohydrate (A antibody), in differentiating rheumatic from nonrheumatic mitral disease was explored. Sera from 154 children with mitral disease were studied. Fifteen of 17 patients with chronic mitral insufficiency (MI) following acute rheumatic fever manifested persistence of elevated A antibody levels following the decline of ASO and anti DNAse B titers to normal 18-36 mth after their acute illness. This antibody pattern was not observed among sera from 35 patients with congenital mitral valve deformities. Serologic study of 71 children with mitral disease of obscure etiology identified three groups: subgroup A includes those 12 who demonstrated the antibody pattern associated with rheumatic MI, while subgroup B is comprised of 39 children with normal A antibody levels. Twenty patients (subgroup C) manifested evidence of recent streptococcal infection. These data suggest that the use of the A antibody test in conjunction with other streptococcal antibody tests is of potential value in differentiating rheumatic from nonrheumatic mitral disease.

Original languageEnglish
Pages (from-to)1244-1251
Number of pages8
JournalCirculation
Volume50
Issue number6
StatePublished - Dec 1 1974
Externally publishedYes

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Mitral Valve
Antibody Formation
Antigens
Antibodies
Mitral Valve Insufficiency
Streptococcal Infections
Rheumatic Fever
Serum
Anti-Idiotypic Antibodies
Carbohydrates

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Shulman, S. T., Ayoub, E. M., Victorica, B. E., Gessner, I. H., Tamer, D. F., & Hernandez, F. A. (1974). Differences in antibody response to streptococcal antigens in children with rheumatic and non rheumatic mitral valve disease. Circulation, 50(6), 1244-1251.

Differences in antibody response to streptococcal antigens in children with rheumatic and non rheumatic mitral valve disease. / Shulman, S. T.; Ayoub, E. M.; Victorica, B. E.; Gessner, I. H.; Tamer, D. F.; Hernandez, F. A.

In: Circulation, Vol. 50, No. 6, 01.12.1974, p. 1244-1251.

Research output: Contribution to journalArticle

Shulman, ST, Ayoub, EM, Victorica, BE, Gessner, IH, Tamer, DF & Hernandez, FA 1974, 'Differences in antibody response to streptococcal antigens in children with rheumatic and non rheumatic mitral valve disease', Circulation, vol. 50, no. 6, pp. 1244-1251.
Shulman ST, Ayoub EM, Victorica BE, Gessner IH, Tamer DF, Hernandez FA. Differences in antibody response to streptococcal antigens in children with rheumatic and non rheumatic mitral valve disease. Circulation. 1974 Dec 1;50(6):1244-1251.
Shulman, S. T. ; Ayoub, E. M. ; Victorica, B. E. ; Gessner, I. H. ; Tamer, D. F. ; Hernandez, F. A. / Differences in antibody response to streptococcal antigens in children with rheumatic and non rheumatic mitral valve disease. In: Circulation. 1974 ; Vol. 50, No. 6. pp. 1244-1251.
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