Differences between cytoplasmic glucocorticoid-binding proteins shown by heterogeneity of nuclear acceptor sites

Marc E. Lippman; E. Brad Thompson

doi:10.1038/246352a0

Differences between cytoplasmic glucocorticoid-binding proteins shown by heterogeneity of nuclear acceptor sites

Marc E. Lippman, E. Brad Thompson

Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

In this report, evidence is presented that at least some degree of specificity of response may be mediated by subtle differences in the cytoplasmic corticosteroid binding proteins between tissues with differing kinds of responses to glucocorticoids. The data further suggest that there are intranuclear binding sites for cytoplasmic glucocorticoid receptors which are of high affinity and saturability and which can distinguish between glucocorticoid receptors of differing origin.

Original language	English (US)
Pages (from-to)	352-355
Number of pages	4
Journal	Nature
Volume	246
Issue number	5432
DOIs	https://doi.org/10.1038/246352a0
State	Published - 1973

ASJC Scopus subject areas

General

Access to Document

10.1038/246352a0

Fingerprint Dive into the research topics of 'Differences between cytoplasmic glucocorticoid-binding proteins shown by heterogeneity of nuclear acceptor sites'. Together they form a unique fingerprint.

Cite this

@article{36913019fbf54813ac64a69f8de735d0,

title = "Differences between cytoplasmic glucocorticoid-binding proteins shown by heterogeneity of nuclear acceptor sites",

abstract = "In this report, evidence is presented that at least some degree of specificity of response may be mediated by subtle differences in the cytoplasmic corticosteroid binding proteins between tissues with differing kinds of responses to glucocorticoids. The data further suggest that there are intranuclear binding sites for cytoplasmic glucocorticoid receptors which are of high affinity and saturability and which can distinguish between glucocorticoid receptors of differing origin.",

author = "Lippman, {Marc E.} and Thompson, {E. Brad}",

year = "1973",

doi = "10.1038/246352a0",

language = "English (US)",

volume = "246",

pages = "352--355",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "5432",

}

TY - JOUR

T1 - Differences between cytoplasmic glucocorticoid-binding proteins shown by heterogeneity of nuclear acceptor sites

AU - Lippman, Marc E.

AU - Thompson, E. Brad

PY - 1973

Y1 - 1973

N2 - In this report, evidence is presented that at least some degree of specificity of response may be mediated by subtle differences in the cytoplasmic corticosteroid binding proteins between tissues with differing kinds of responses to glucocorticoids. The data further suggest that there are intranuclear binding sites for cytoplasmic glucocorticoid receptors which are of high affinity and saturability and which can distinguish between glucocorticoid receptors of differing origin.

AB - In this report, evidence is presented that at least some degree of specificity of response may be mediated by subtle differences in the cytoplasmic corticosteroid binding proteins between tissues with differing kinds of responses to glucocorticoids. The data further suggest that there are intranuclear binding sites for cytoplasmic glucocorticoid receptors which are of high affinity and saturability and which can distinguish between glucocorticoid receptors of differing origin.

UR - http://www.scopus.com/inward/record.url?scp=0015898443&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015898443&partnerID=8YFLogxK

U2 - 10.1038/246352a0

DO - 10.1038/246352a0

M3 - Article

C2 - 4357249

AN - SCOPUS:0015898443

VL - 246

SP - 352

EP - 355

JO - Nature

JF - Nature

SN - 0028-0836

IS - 5432

ER -