Abstract
In this report, evidence is presented that at least some degree of specificity of response may be mediated by subtle differences in the cytoplasmic corticosteroid binding proteins between tissues with differing kinds of responses to glucocorticoids. The data further suggest that there are intranuclear binding sites for cytoplasmic glucocorticoid receptors which are of high affinity and saturability and which can distinguish between glucocorticoid receptors of differing origin.
| Original language | English |
|---|---|
| Pages (from-to) | 352-355 |
| Number of pages | 4 |
| Journal | Nature |
| Volume | 246 |
| Issue number | 5432 |
| State | Published - Dec 1 1973 |
| Externally published | Yes |
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Cite this
Differences between cytoplasmic glucocorticoid binding proteins shown by heterogeneity of nuclear acceptor sites. / Lippman, Marc E; Thompson, E. B.
In: Nature, Vol. 246, No. 5432, 01.12.1973, p. 352-355.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differences between cytoplasmic glucocorticoid binding proteins shown by heterogeneity of nuclear acceptor sites
AU - Lippman, Marc E
AU - Thompson, E. B.
PY - 1973/12/1
Y1 - 1973/12/1
N2 - In this report, evidence is presented that at least some degree of specificity of response may be mediated by subtle differences in the cytoplasmic corticosteroid binding proteins between tissues with differing kinds of responses to glucocorticoids. The data further suggest that there are intranuclear binding sites for cytoplasmic glucocorticoid receptors which are of high affinity and saturability and which can distinguish between glucocorticoid receptors of differing origin.
AB - In this report, evidence is presented that at least some degree of specificity of response may be mediated by subtle differences in the cytoplasmic corticosteroid binding proteins between tissues with differing kinds of responses to glucocorticoids. The data further suggest that there are intranuclear binding sites for cytoplasmic glucocorticoid receptors which are of high affinity and saturability and which can distinguish between glucocorticoid receptors of differing origin.
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UR - http://www.scopus.com/inward/citedby.url?scp=0015898443&partnerID=8YFLogxK
M3 - Article
C2 - 4357249
AN - SCOPUS:0015898443
VL - 246
SP - 352
EP - 355
JO - Nature
JF - Nature
SN - 0028-0836
IS - 5432
ER -