Differences between cytoplasmic glucocorticoid-binding proteins shown by heterogeneity of nuclear acceptor sites

In this report, evidence is presented that at least some degree of specificity of response may be mediated by subtle differences in the cytoplasmic corticosteroid binding proteins between tissues with differing kinds of responses to glucocorticoids. The data further suggest that there are intranuclear binding sites for cytoplasmic glucocorticoid receptors which are of high affinity and saturability and which can distinguish between glucocorticoid receptors of differing origin.