Dietary restriction, mitochondrial function and aging: From yeast to humans

Andrea Ruetenik, Antonio Barrientos

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Dietary restriction (DR) attenuates many detrimental effects of aging and consequently promotes health and increases longevity across organisms. While over the last 15 years extensive research has been devoted towards understanding the biology of aging, the precise mechanistic aspects of DR are yet to be settled. Abundant experimental evidence indicates that the DR effect on stimulating health impinges several metabolic and stress-resistance pathways. Downstream effects of these pathways include a reduction in cellular damage induced by oxidative stress, enhanced efficiency of mitochondrial functions and maintenance of mitochondrial dynamics and quality control, thereby attenuating age-related declines in mitochondrial function. However, the literature also accumulates conflicting evidence regarding how DR ameliorates mitochondrial performance and whether that is enough to slow age-dependent cellular and organismal deterioration. Here, we will summarize the current knowledge about how and to which extent the influence of different DR regimes on mitochondrial biogenesis and function contribute to postpone the detrimental effects of aging on healthspan and lifespan. This article is part of a Special Issue entitled: Mitochondrial Dysfunction in Aging.

Original languageEnglish (US)
Pages (from-to)1434-1447
Number of pages14
JournalBiochimica et Biophysica Acta - Bioenergetics
Volume1847
Issue number11
DOIs
StatePublished - Mar 19 2015

Keywords

  • Aging
  • Dietary restriction
  • Longevity
  • Mitochondria
  • OXPHOS
  • TORC1

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology

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