Dietary Fatty Acids Correlate With Prostate Cancer Biopsy Grade and Volume in Jamaican Men

Chad R. Ritch, Robert L. Wan, Leonard B. Stephens, Jerome B. Taxy, Dezheng Huo, Edward M. Gong, Gregory P. Zagaja, Charles B. Brendler

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Purpose: Jamaica has the highest incidence of prostate cancer in the world. Dietary fat is associated with prostate cancer. The Ω6 polyunsaturated fatty acids have been shown to stimulate prostate carcinogenesis and the Jamaican diet is rich in linoleic acid. We hypothesized positive correlations between Ω6 polyunsaturated fatty acid, prostate specific antigen and prostate biopsy pathology. Materials and Methods: A total of 148 men were enrolled in Kingston, Jamaica. Serum prostate specific antigen and erythrocyte membrane polyunsaturated fatty acids were analyzed. Men with prostate specific antigen 2.6 ng/ml or greater underwent biopsy. Histopathological and statistical analyses were performed on available data. Results: Of the 54 men who underwent biopsy 24 had prostate cancer, 17 had a Gleason score of 7 or greater and 11 had a tumor volume of 50% or greater. There were significant positive correlations between linoleic acid and Gleason score (p = 0.009), and the linoleic acid-to-docosahexaenoic acid (Ω3) ratio and tumor volume (p = 0.03). There was a significant negative correlation between the arachidonic acid (Ω6)-to-docosapentanoic acid (Ω3) ratio and Gleason score (p = 0.04). Statistical correlations between prostate specific antigen and polyunsaturated fatty acids were inconsistent. Conclusions: The positive correlations between linoleic acid and Gleason score, and the linoleic acid-to-docosahexaenoic acid ratio and tumor volume support studies showing that Ω6 polyunsaturated fatty acids stimulate and Ω3 polyunsaturated fatty acids inhibit prostate cancer growth. The negative correlation between the arachidonic acid-to-docosapentanoic acid ratio and Gleason score supports studies that demonstrate increased metabolism of arachidonic acid in prostate cancer to form carcinogenic metabolites, namely prostaglandin E2. Our findings support the association between dietary fatty acids and prostate cancer, and they warrant further dietary and tissue studies in high risk populations.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalJournal of Urology
Volume177
Issue number1
DOIs
StatePublished - Jan 1 2007

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Keywords

  • dietary fats
  • fatty acids
  • prostate
  • prostate-specific antigen
  • prostatic neoplasms
  • unsaturated

ASJC Scopus subject areas

  • Urology

Cite this

Ritch, C. R., Wan, R. L., Stephens, L. B., Taxy, J. B., Huo, D., Gong, E. M., Zagaja, G. P., & Brendler, C. B. (2007). Dietary Fatty Acids Correlate With Prostate Cancer Biopsy Grade and Volume in Jamaican Men. Journal of Urology, 177(1), 97-101. https://doi.org/10.1016/j.juro.2006.08.105