Dietary Ca inhibits waterborne Cd uptake in Cd-exposed rainbow trout, Oncorhynchus mykiss

Mohammad Ali Zohouri, Greg G. Pyle, Chris M. Wood

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

The effects of chronic exposure to waterborne Cd and elevated dietary Ca, alone and in combination, were examined in juvenile rainbow trout, Oncorhynchus mykiss. Fish were chronically exposed to 0.05 (control) or 2.56 μg/l Cd [as Cd(NO3)2·4H2O] and were fed 2% body mass/day of control (29.6 mg Ca/g) or Ca-supplemented trout food (52.8 mg Ca/g as CaCl2·2H2O). Cd accumulated mainly in gill, liver, and kidney. Waterborne Cd inhibited unidirectional Ca uptake from water into the gill and induced hypocalcemia in the plasma on day 40. Waterborne Cd also induced an elevated Ca concentration on day 20 in the gill tissue of trout fed the Ca-supplemented diet and a decreased Ca concentration on day 35 in the gills of trout fed the control diet. Dietary Ca protected against Cd accumulation in gill, liver, and kidney, but did not protect against the inhibition of Ca uptake into the gill or plasma hypocalcemia. When fed Ca-supplemented diet and exposed to waterborne Cd, fish showed 35% mortality, compared to 0-2% in control fish and in the Cd-exposed fish with normal Ca in the diet. Growth, on the other hand, was not affected by any treatment.

Original languageEnglish (US)
Pages (from-to)347-356
Number of pages10
JournalComparative Biochemistry and Physiology - C Toxicology and Pharmacology
Volume130
Issue number3
DOIs
StatePublished - Jan 1 2001

Keywords

  • Dietary calcium
  • Gill
  • Hypocalcemia
  • Oncorhynchus mykiss
  • Rainbow trout
  • Waterborne cadmium

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Health, Toxicology and Mutagenesis
  • Pharmacology

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