Diet as a Trigger or Therapy for Inflammatory Bowel Diseases

James D. Lewis, Maria T Abreu

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

The most common question asked by patients with inflammatory bowel disease (IBD) is, “Doctor, what should I eat?” Findings from epidemiology studies have indicated that diets high in animal fat and low in fruits and vegetables are the most common pattern associated with an increased risk of IBD. Low levels of vitamin D also appear to be a risk factor for IBD. In murine models, diets high in fat, especially saturated animal fats, also increase inflammation, whereas supplementation with omega 3 long-chain fatty acids protect against intestinal inflammation. Unfortunately, omega 3 supplements have not been shown to decrease the risk of relapse in patients with Crohn's disease. Dietary intervention studies have shown that enteral therapy, with defined formula diets, helps children with Crohn's disease and reduces inflammation and dysbiosis. Although fiber supplements have not been shown definitively to benefit patients with IBD, soluble fiber is the best way to generate short-chain fatty acids such as butyrate, which has anti-inflammatory effects. Addition of vitamin D and curcumin has been shown to increase the efficacy of IBD therapy. There is compelling evidence from animal models that emulsifiers in processed foods increase risk for IBD. We discuss current knowledge about popular diets, including the specific carbohydrate diet and diet low in fermentable oligo-, di-, and monosaccharides and polyols. We present findings from clinical and basic science studies to help gastroenterologists navigate diet as it relates to the management of IBD.

Original languageEnglish (US)
Pages (from-to)398-414.e6
JournalGastroenterology
Volume152
Issue number2
DOIs
StatePublished - Feb 1 2017

Fingerprint

Inflammatory Bowel Diseases
Diet
Inflammation
Vitamin D
Crohn Disease
Therapeutics
Fats
Dysbiosis
Formulated Food
Curcumin
Volatile Fatty Acids
Monosaccharides
Butyrates
Disaccharides
High Fat Diet
Vegetables
Small Intestine
Fruit
Epidemiology
Anti-Inflammatory Agents

Keywords

  • Diet
  • Inflammatory Bowel Disease
  • Microbiome
  • Short-Chain Fatty Acids

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Diet as a Trigger or Therapy for Inflammatory Bowel Diseases. / Lewis, James D.; Abreu, Maria T.

In: Gastroenterology, Vol. 152, No. 2, 01.02.2017, p. 398-414.e6.

Research output: Contribution to journalArticle

Lewis, James D. ; Abreu, Maria T. / Diet as a Trigger or Therapy for Inflammatory Bowel Diseases. In: Gastroenterology. 2017 ; Vol. 152, No. 2. pp. 398-414.e6.
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