Dibenzocycloalkenimine (MK-801) stimulates phosphoinositide hydrolysis in rat cerebral cortical slices

G. C. Ormandy, X. Li, R. S. Jope

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Dibenzocycloalkenimine (MK-801), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, induced a concentration-dependent accumulation of inositol monophosphate in rat cerebral cortical slices. This effect appears unrelated to antagonism of NMDA receptors as AP-7 and PCP did not cause comparable effects. In addition, the MK-801-induced response was unaffected by NMDA or glycine, alone or in combination, Zn2+, or the removal of Mg2+ from the buffer. These results indicate a novel site of action for MK-801 associated with activation of phosphoinositide hydrolysis.

Original languageEnglish (US)
Pages (from-to)779-782
Number of pages4
JournalNeuropharmacology
Volume29
Issue number8
DOIs
StatePublished - Aug 1990
Externally publishedYes

Keywords

  • MK-801
  • phosphoinositide hydrolysis

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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