Dibenzocycloalkenimine (MK-801) stimulates phosphoinositide hydrolysis in rat cerebral cortical slices

G. C. Ormandy, X. Li, Richard S Jope

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Dibenzocycloalkenimine (MK-801), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, induced a concentration-dependent accumulation of inositol monophosphate in rat cerebral cortical slices. This effect appears unrelated to antagonism of NMDA receptors as AP-7 and PCP did not cause comparable effects. In addition, the MK-801-induced response was unaffected by NMDA or glycine, alone or in combination, Zn2+, or the removal of Mg2+ from the buffer. These results indicate a novel site of action for MK-801 associated with activation of phosphoinositide hydrolysis.

Original languageEnglish
Pages (from-to)779-782
Number of pages4
JournalNeuropharmacology
Volume29
Issue number8
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Dizocilpine Maleate
Phosphatidylinositols
Hydrolysis
N-Methyl-D-Aspartate Receptors
Sarcosine
Inositol
N-Methylaspartate
Buffers

Keywords

  • MK-801
  • phosphoinositide hydrolysis

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Dibenzocycloalkenimine (MK-801) stimulates phosphoinositide hydrolysis in rat cerebral cortical slices. / Ormandy, G. C.; Li, X.; Jope, Richard S.

In: Neuropharmacology, Vol. 29, No. 8, 01.01.1990, p. 779-782.

Research output: Contribution to journalArticle

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