Diagnostic transvitreal fine-needle aspiration biopsy of small melanocytic choroidal tumors in nevus versus melanoma category

James J. Augsburger, Zélia M. Corrêa, Susan Schneider, Rawia S. Yassin, Toni Robinson-Smith, Hormoz Ehya, Nikolaos Trichopoulos, Hans E. Grossniklaus, Stephen S. Feman, Froncie A. Gutman, Richard Forster, Vinod Lakhanpal, J. Brooks Crawford

Research output: Contribution to journalArticle

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Abstract

Purpose: To report an experience with fine-needle aspiration biopsy of selected small melanocytic choroidal tumors during the interval from April 13, 1983, through January 19, 2001. Methods: Retrospective descriptive case series report of 34 patients with a small melanocytic choroidal tumor (maximal diameter, ≤10 mm; thielmess, ≥1.5 mm but ≤3 mm) evaluated diagnostically by transvitreal fine-needle aspiration biopsy prior to treatment. None of the tumors had invasive features at the time of biopsy. Results: Patients ranged in age from 26 to 73 years (mean, 50.9 years). The evaluated choroidal tumors had a mean maximal basal diameter of 8.0 mm and a mean maximal thickness of 2.4 mm. Eighteen of the 34 tumors (52.9%) had been documented to enlarge prior to biopsy. Biopsy was performed in all cases using a 25-gauge hollow lumen needle and a transvitreal approach via a pars plana puncture site. The biopsy yielded a sufficient aspirate for cytodiagnosis in 22 of 34 cases (64.7%). In these cases, the tumor was classified as malignant melanoma in 16 (47.1% of total), intermediate lesion in 4 (11.8%), and benign nevus in 2 (5.9%). The 12 tumors that yielded an insufficient aspirate and the four lesions that yielded intermediate cells continued to be classified as "nevus versus melanoma" and were monitored periodically for growth or other changes. Four of the 12 tumors that yielded an insufficient aspirate for cytodiagnosis and all four lesions that yielded intermediate cells were eventually reclassified as small choroidal melanomas and treated. The remaining eight tumors that yielded an insufficient aspirate and the two tumors that yielded benign nevus cells were classified as benign nevi at the most recent follow-up evaluation. Conclusions: Fine-needle aspiration biopsy showed that a substantial proportion of small melanocytic choroidal tumors likely to be classified clinically as small choroidal melanomas in many centers were in fact benign nevi or intermediate lesions.

Original languageEnglish
Pages (from-to)225-234
Number of pages10
JournalTransactions of the American Ophthalmological Society
Volume100
StatePublished - Dec 1 2002
Externally publishedYes

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Nevi and Melanomas
Fine Needle Biopsy
Neoplasms
Nevus
Cytodiagnosis
Biopsy
Melanoma
Temazepam
Punctures
Needles

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Augsburger, J. J., Corrêa, Z. M., Schneider, S., Yassin, R. S., Robinson-Smith, T., Ehya, H., ... Crawford, J. B. (2002). Diagnostic transvitreal fine-needle aspiration biopsy of small melanocytic choroidal tumors in nevus versus melanoma category. Transactions of the American Ophthalmological Society, 100, 225-234.

Diagnostic transvitreal fine-needle aspiration biopsy of small melanocytic choroidal tumors in nevus versus melanoma category. / Augsburger, James J.; Corrêa, Zélia M.; Schneider, Susan; Yassin, Rawia S.; Robinson-Smith, Toni; Ehya, Hormoz; Trichopoulos, Nikolaos; Grossniklaus, Hans E.; Feman, Stephen S.; Gutman, Froncie A.; Forster, Richard; Lakhanpal, Vinod; Crawford, J. Brooks.

In: Transactions of the American Ophthalmological Society, Vol. 100, 01.12.2002, p. 225-234.

Research output: Contribution to journalArticle

Augsburger, JJ, Corrêa, ZM, Schneider, S, Yassin, RS, Robinson-Smith, T, Ehya, H, Trichopoulos, N, Grossniklaus, HE, Feman, SS, Gutman, FA, Forster, R, Lakhanpal, V & Crawford, JB 2002, 'Diagnostic transvitreal fine-needle aspiration biopsy of small melanocytic choroidal tumors in nevus versus melanoma category', Transactions of the American Ophthalmological Society, vol. 100, pp. 225-234.
Augsburger, James J. ; Corrêa, Zélia M. ; Schneider, Susan ; Yassin, Rawia S. ; Robinson-Smith, Toni ; Ehya, Hormoz ; Trichopoulos, Nikolaos ; Grossniklaus, Hans E. ; Feman, Stephen S. ; Gutman, Froncie A. ; Forster, Richard ; Lakhanpal, Vinod ; Crawford, J. Brooks. / Diagnostic transvitreal fine-needle aspiration biopsy of small melanocytic choroidal tumors in nevus versus melanoma category. In: Transactions of the American Ophthalmological Society. 2002 ; Vol. 100. pp. 225-234.
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title = "Diagnostic transvitreal fine-needle aspiration biopsy of small melanocytic choroidal tumors in nevus versus melanoma category",
abstract = "Purpose: To report an experience with fine-needle aspiration biopsy of selected small melanocytic choroidal tumors during the interval from April 13, 1983, through January 19, 2001. Methods: Retrospective descriptive case series report of 34 patients with a small melanocytic choroidal tumor (maximal diameter, ≤10 mm; thielmess, ≥1.5 mm but ≤3 mm) evaluated diagnostically by transvitreal fine-needle aspiration biopsy prior to treatment. None of the tumors had invasive features at the time of biopsy. Results: Patients ranged in age from 26 to 73 years (mean, 50.9 years). The evaluated choroidal tumors had a mean maximal basal diameter of 8.0 mm and a mean maximal thickness of 2.4 mm. Eighteen of the 34 tumors (52.9{\%}) had been documented to enlarge prior to biopsy. Biopsy was performed in all cases using a 25-gauge hollow lumen needle and a transvitreal approach via a pars plana puncture site. The biopsy yielded a sufficient aspirate for cytodiagnosis in 22 of 34 cases (64.7{\%}). In these cases, the tumor was classified as malignant melanoma in 16 (47.1{\%} of total), intermediate lesion in 4 (11.8{\%}), and benign nevus in 2 (5.9{\%}). The 12 tumors that yielded an insufficient aspirate and the four lesions that yielded intermediate cells continued to be classified as {"}nevus versus melanoma{"} and were monitored periodically for growth or other changes. Four of the 12 tumors that yielded an insufficient aspirate for cytodiagnosis and all four lesions that yielded intermediate cells were eventually reclassified as small choroidal melanomas and treated. The remaining eight tumors that yielded an insufficient aspirate and the two tumors that yielded benign nevus cells were classified as benign nevi at the most recent follow-up evaluation. Conclusions: Fine-needle aspiration biopsy showed that a substantial proportion of small melanocytic choroidal tumors likely to be classified clinically as small choroidal melanomas in many centers were in fact benign nevi or intermediate lesions.",
author = "Augsburger, {James J.} and Corr{\^e}a, {Z{\'e}lia M.} and Susan Schneider and Yassin, {Rawia S.} and Toni Robinson-Smith and Hormoz Ehya and Nikolaos Trichopoulos and Grossniklaus, {Hans E.} and Feman, {Stephen S.} and Gutman, {Froncie A.} and Richard Forster and Vinod Lakhanpal and Crawford, {J. Brooks}",
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T1 - Diagnostic transvitreal fine-needle aspiration biopsy of small melanocytic choroidal tumors in nevus versus melanoma category

AU - Augsburger, James J.

AU - Corrêa, Zélia M.

AU - Schneider, Susan

AU - Yassin, Rawia S.

AU - Robinson-Smith, Toni

AU - Ehya, Hormoz

AU - Trichopoulos, Nikolaos

AU - Grossniklaus, Hans E.

AU - Feman, Stephen S.

AU - Gutman, Froncie A.

AU - Forster, Richard

AU - Lakhanpal, Vinod

AU - Crawford, J. Brooks

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Y1 - 2002/12/1

N2 - Purpose: To report an experience with fine-needle aspiration biopsy of selected small melanocytic choroidal tumors during the interval from April 13, 1983, through January 19, 2001. Methods: Retrospective descriptive case series report of 34 patients with a small melanocytic choroidal tumor (maximal diameter, ≤10 mm; thielmess, ≥1.5 mm but ≤3 mm) evaluated diagnostically by transvitreal fine-needle aspiration biopsy prior to treatment. None of the tumors had invasive features at the time of biopsy. Results: Patients ranged in age from 26 to 73 years (mean, 50.9 years). The evaluated choroidal tumors had a mean maximal basal diameter of 8.0 mm and a mean maximal thickness of 2.4 mm. Eighteen of the 34 tumors (52.9%) had been documented to enlarge prior to biopsy. Biopsy was performed in all cases using a 25-gauge hollow lumen needle and a transvitreal approach via a pars plana puncture site. The biopsy yielded a sufficient aspirate for cytodiagnosis in 22 of 34 cases (64.7%). In these cases, the tumor was classified as malignant melanoma in 16 (47.1% of total), intermediate lesion in 4 (11.8%), and benign nevus in 2 (5.9%). The 12 tumors that yielded an insufficient aspirate and the four lesions that yielded intermediate cells continued to be classified as "nevus versus melanoma" and were monitored periodically for growth or other changes. Four of the 12 tumors that yielded an insufficient aspirate for cytodiagnosis and all four lesions that yielded intermediate cells were eventually reclassified as small choroidal melanomas and treated. The remaining eight tumors that yielded an insufficient aspirate and the two tumors that yielded benign nevus cells were classified as benign nevi at the most recent follow-up evaluation. Conclusions: Fine-needle aspiration biopsy showed that a substantial proportion of small melanocytic choroidal tumors likely to be classified clinically as small choroidal melanomas in many centers were in fact benign nevi or intermediate lesions.

AB - Purpose: To report an experience with fine-needle aspiration biopsy of selected small melanocytic choroidal tumors during the interval from April 13, 1983, through January 19, 2001. Methods: Retrospective descriptive case series report of 34 patients with a small melanocytic choroidal tumor (maximal diameter, ≤10 mm; thielmess, ≥1.5 mm but ≤3 mm) evaluated diagnostically by transvitreal fine-needle aspiration biopsy prior to treatment. None of the tumors had invasive features at the time of biopsy. Results: Patients ranged in age from 26 to 73 years (mean, 50.9 years). The evaluated choroidal tumors had a mean maximal basal diameter of 8.0 mm and a mean maximal thickness of 2.4 mm. Eighteen of the 34 tumors (52.9%) had been documented to enlarge prior to biopsy. Biopsy was performed in all cases using a 25-gauge hollow lumen needle and a transvitreal approach via a pars plana puncture site. The biopsy yielded a sufficient aspirate for cytodiagnosis in 22 of 34 cases (64.7%). In these cases, the tumor was classified as malignant melanoma in 16 (47.1% of total), intermediate lesion in 4 (11.8%), and benign nevus in 2 (5.9%). The 12 tumors that yielded an insufficient aspirate and the four lesions that yielded intermediate cells continued to be classified as "nevus versus melanoma" and were monitored periodically for growth or other changes. Four of the 12 tumors that yielded an insufficient aspirate for cytodiagnosis and all four lesions that yielded intermediate cells were eventually reclassified as small choroidal melanomas and treated. The remaining eight tumors that yielded an insufficient aspirate and the two tumors that yielded benign nevus cells were classified as benign nevi at the most recent follow-up evaluation. Conclusions: Fine-needle aspiration biopsy showed that a substantial proportion of small melanocytic choroidal tumors likely to be classified clinically as small choroidal melanomas in many centers were in fact benign nevi or intermediate lesions.

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