Diagnostic testing and treatment choices in primary vitreoretinal lymphoma

Rithwick Rajagopal, J. William Harbour

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

BACKGROUND: Primary vitreoretinal lymphoma is a rare intraocular malignancy often seen in the context of central nervous system lymphoma. This review updates the current approaches to the management of primary vitreoretinal lymphoma. METHODS: A review of current literature on the management of primary vitreoretinal lymphoma with an emphasis on contemporary diagnostic and treatment methods. RESULTS: Techniques for diagnosing primary vitreoretinal lymphoma from ocular biopsy specimens include cytologic analysis, immunocytochemistry, flow cytometry, polymerase chain reaction to detect V-J immunoglobulin gene rearrangements, and analysis of IL-6 and IL-10 in aqueous or vitreous fluid. Treatment options include external beam radiotherapy, systemic chemotherapy, and intravitreal chemotherapy. CONCLUSION: Cytologic examination of intraocular biopsy specimens remains the gold standard for the diagnosis of PVRL, but ancillary tests can be very helpful in selected patients. Successful primary treatment of the eyes can be accomplished with external beam radiotherapy or intravitreal chemotherapy. Management decisions should be individualized on patient factors, local expertise, and patient preferences. Improvements in molecular diagnostics and local drug delivery are needed to improve the management of PVRL.

Original languageEnglish
Pages (from-to)435-440
Number of pages6
JournalRetina
Volume31
Issue number3
DOIs
StatePublished - Mar 1 2011
Externally publishedYes

Fingerprint

Lymphoma
Drug Therapy
Radiotherapy
Biopsy
Therapeutics
Immunoglobulin Genes
Molecular Pathology
Patient Preference
Gene Rearrangement
Interleukin-10
Interleukin-6
Flow Cytometry
Central Nervous System
Immunohistochemistry
Polymerase Chain Reaction
Pharmaceutical Preparations
Neoplasms

Keywords

  • CNS lymphoma
  • external beam radiotherapy
  • intraocular lymphoma
  • methotrexate
  • rituximab
  • vitreoretinal lymphoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Diagnostic testing and treatment choices in primary vitreoretinal lymphoma. / Rajagopal, Rithwick; William Harbour, J.

In: Retina, Vol. 31, No. 3, 01.03.2011, p. 435-440.

Research output: Contribution to journalArticle

@article{9afdd120ee924869b54e32628b42f0e0,
title = "Diagnostic testing and treatment choices in primary vitreoretinal lymphoma",
abstract = "BACKGROUND: Primary vitreoretinal lymphoma is a rare intraocular malignancy often seen in the context of central nervous system lymphoma. This review updates the current approaches to the management of primary vitreoretinal lymphoma. METHODS: A review of current literature on the management of primary vitreoretinal lymphoma with an emphasis on contemporary diagnostic and treatment methods. RESULTS: Techniques for diagnosing primary vitreoretinal lymphoma from ocular biopsy specimens include cytologic analysis, immunocytochemistry, flow cytometry, polymerase chain reaction to detect V-J immunoglobulin gene rearrangements, and analysis of IL-6 and IL-10 in aqueous or vitreous fluid. Treatment options include external beam radiotherapy, systemic chemotherapy, and intravitreal chemotherapy. CONCLUSION: Cytologic examination of intraocular biopsy specimens remains the gold standard for the diagnosis of PVRL, but ancillary tests can be very helpful in selected patients. Successful primary treatment of the eyes can be accomplished with external beam radiotherapy or intravitreal chemotherapy. Management decisions should be individualized on patient factors, local expertise, and patient preferences. Improvements in molecular diagnostics and local drug delivery are needed to improve the management of PVRL.",
keywords = "CNS lymphoma, external beam radiotherapy, intraocular lymphoma, methotrexate, rituximab, vitreoretinal lymphoma",
author = "Rithwick Rajagopal and {William Harbour}, J.",
year = "2011",
month = "3",
day = "1",
doi = "10.1097/IAE.0b013e31820a6743",
language = "English",
volume = "31",
pages = "435--440",
journal = "Retina",
issn = "0275-004X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Diagnostic testing and treatment choices in primary vitreoretinal lymphoma

AU - Rajagopal, Rithwick

AU - William Harbour, J.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - BACKGROUND: Primary vitreoretinal lymphoma is a rare intraocular malignancy often seen in the context of central nervous system lymphoma. This review updates the current approaches to the management of primary vitreoretinal lymphoma. METHODS: A review of current literature on the management of primary vitreoretinal lymphoma with an emphasis on contemporary diagnostic and treatment methods. RESULTS: Techniques for diagnosing primary vitreoretinal lymphoma from ocular biopsy specimens include cytologic analysis, immunocytochemistry, flow cytometry, polymerase chain reaction to detect V-J immunoglobulin gene rearrangements, and analysis of IL-6 and IL-10 in aqueous or vitreous fluid. Treatment options include external beam radiotherapy, systemic chemotherapy, and intravitreal chemotherapy. CONCLUSION: Cytologic examination of intraocular biopsy specimens remains the gold standard for the diagnosis of PVRL, but ancillary tests can be very helpful in selected patients. Successful primary treatment of the eyes can be accomplished with external beam radiotherapy or intravitreal chemotherapy. Management decisions should be individualized on patient factors, local expertise, and patient preferences. Improvements in molecular diagnostics and local drug delivery are needed to improve the management of PVRL.

AB - BACKGROUND: Primary vitreoretinal lymphoma is a rare intraocular malignancy often seen in the context of central nervous system lymphoma. This review updates the current approaches to the management of primary vitreoretinal lymphoma. METHODS: A review of current literature on the management of primary vitreoretinal lymphoma with an emphasis on contemporary diagnostic and treatment methods. RESULTS: Techniques for diagnosing primary vitreoretinal lymphoma from ocular biopsy specimens include cytologic analysis, immunocytochemistry, flow cytometry, polymerase chain reaction to detect V-J immunoglobulin gene rearrangements, and analysis of IL-6 and IL-10 in aqueous or vitreous fluid. Treatment options include external beam radiotherapy, systemic chemotherapy, and intravitreal chemotherapy. CONCLUSION: Cytologic examination of intraocular biopsy specimens remains the gold standard for the diagnosis of PVRL, but ancillary tests can be very helpful in selected patients. Successful primary treatment of the eyes can be accomplished with external beam radiotherapy or intravitreal chemotherapy. Management decisions should be individualized on patient factors, local expertise, and patient preferences. Improvements in molecular diagnostics and local drug delivery are needed to improve the management of PVRL.

KW - CNS lymphoma

KW - external beam radiotherapy

KW - intraocular lymphoma

KW - methotrexate

KW - rituximab

KW - vitreoretinal lymphoma

UR - http://www.scopus.com/inward/record.url?scp=79952293028&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952293028&partnerID=8YFLogxK

U2 - 10.1097/IAE.0b013e31820a6743

DO - 10.1097/IAE.0b013e31820a6743

M3 - Article

C2 - 21336066

AN - SCOPUS:79952293028

VL - 31

SP - 435

EP - 440

JO - Retina

JF - Retina

SN - 0275-004X

IS - 3

ER -