Diagnostic Studies in Patients With Sickle Cell Anemia and Acute Abdominal Pain

Aldo N. Serafini, Gabriel Spoliansky, George N. Sfakianakis, Berta Montalvo, Wallace N. Jensen

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Twenty-eight patients with sickle cell disease who presented with acute abdominal pain were evaluated with clinical laboratory, ultrasound, and biliary scintigraphic studies to determine their predictive capabilities for differentiating venoocclusive disease (sickle cell crisis) from acute biliary disease. Eleven patients were treated surgically and 17 medically. Gallstones were demonstrated in 25 (90%) of the patients studied by ultrasound, and biliary scans were abnormal in nine patients (32%). Abnormal laboratory and radiological studies (ultrasound, biliary scintigraphy) were not significantly different in the two groups and had a low positive predictive value for detection of acute biliary disease. Nevertheless, normal biliary scintigraphy had high negative predictive value in that, if normal, it gave assurance that the cystic duct was patent and unnecessary surgery could be obviated in this high-risk category of patients.

Original languageEnglish (US)
Pages (from-to)1061-1062
Number of pages2
JournalArchives of internal medicine
Issue number6
StatePublished - Jun 1987

ASJC Scopus subject areas

  • Internal Medicine


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