Diagnostic reliability of bipolar II disorder

Sylvia G. Simpson, Francis J. McMahon, Melvin G. McInnis, Dean F. MacKinnon, David Edwin, Susan E. Folstein, J. Raymond DePaulo

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Background: Although the diagnostic reliability of major depression and mania has been well established, that of hypomania and bipolar II (BPII) disorder has not. This remains an important issue for clinicians, especially for those undertaking genetic studies of BP disorder since bipolar I (BPI) and BPII disorders often cluster in the same families. We have assessed our diagnostic reliability of BP disorders, recurrent unipolar disorder, and their constituent episodes (major depression, mania, and hypomania) using interview and best-estimate diagnostic procedures used in a genetic study of families with BPI disorder. Methods: Reliability was assessed for (1) co-rated Schedule for Affective Disorders and Schizophrenia-Lifetime version interviews of 37 subjects including 15 with BP disorders; (2) test-retest Schedule for Affective Disorders and Schizophrenia-Lifetime version interviews of 26 subjects including 13 with BP disorders; and (3) best-estimate diagnoses made by 2 non-interviewing psychiatrists on 524 subjects in a genetic linkage study of BPI disorder. Diagnoses were based on Research Diagnostic Criteria for a Selected Group of Functional Disorders, except that recurrent major depression as well as hypomania was required for a diagnosis of BPII disorder. Results: On co-rated interviews, we observed complete agreement between interviewers for diagnosing major depressive, manic, and hypomanic episodes. For testretest interviews, the Cohen κ coefficients were 0.83 for manic, 0.72 for hypomanic, and 1.0 for major depressive episodes. At the best-estimate level, the Cohen K coefficients were 0.99 for BPI, 0.99 for BPII, and 0.98 for recurrent unipolar disorder. Conclusion: Good interrater reliability for BPII can be achieved when the interviews and best-estimate diagnoses are done by experienced psychiatrists.

Original languageEnglish
Pages (from-to)736-740
Number of pages5
JournalArchives of General Psychiatry
Volume59
Issue number8
StatePublished - Aug 15 2002

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Bipolar Disorder
Interviews
Depression
Mood Disorders
Psychiatry
Schizophrenia
Appointments and Schedules
Genetic Linkage
Research

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Simpson, S. G., McMahon, F. J., McInnis, M. G., MacKinnon, D. F., Edwin, D., Folstein, S. E., & Raymond DePaulo, J. (2002). Diagnostic reliability of bipolar II disorder. Archives of General Psychiatry, 59(8), 736-740.

Diagnostic reliability of bipolar II disorder. / Simpson, Sylvia G.; McMahon, Francis J.; McInnis, Melvin G.; MacKinnon, Dean F.; Edwin, David; Folstein, Susan E.; Raymond DePaulo, J.

In: Archives of General Psychiatry, Vol. 59, No. 8, 15.08.2002, p. 736-740.

Research output: Contribution to journalArticle

Simpson, SG, McMahon, FJ, McInnis, MG, MacKinnon, DF, Edwin, D, Folstein, SE & Raymond DePaulo, J 2002, 'Diagnostic reliability of bipolar II disorder', Archives of General Psychiatry, vol. 59, no. 8, pp. 736-740.
Simpson SG, McMahon FJ, McInnis MG, MacKinnon DF, Edwin D, Folstein SE et al. Diagnostic reliability of bipolar II disorder. Archives of General Psychiatry. 2002 Aug 15;59(8):736-740.
Simpson, Sylvia G. ; McMahon, Francis J. ; McInnis, Melvin G. ; MacKinnon, Dean F. ; Edwin, David ; Folstein, Susan E. ; Raymond DePaulo, J. / Diagnostic reliability of bipolar II disorder. In: Archives of General Psychiatry. 2002 ; Vol. 59, No. 8. pp. 736-740.
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