Diagnostic interview assessed neuropsychiatric disorder comorbidity in 334 individuals with obsessive-compulsive disorder

V. Holland LaSalle, Kiara R. Cromer, Kathryn N. Nelson, Diane Kazuba, Lucy Justement, Dennis L. Murphy

Research output: Contribution to journalArticle

108 Scopus citations

Abstract

Is obsessive-compulsive disorder (OCD) a discrete disorder? Three hundred thirty-four individuals with OCD were interviewed using the Structured Clinical Interview for DSM (SCID). Results demonstrate that OCD is highly comorbid with other neuropsychiatric disorders, with 92% of OCD study participants receiving one or more additional Axis I DSM diagnoses. Among these additional diagnoses, lifetime mood disorders (81%) and anxiety disorders (53%) were the most prevalent. With the exception of substance-related disorders and specific phobias, all disorders assessed were found in considerably higher frequency than in the general population, indicating that OCD is associated with highly complex comorbidity. These data have implications for genetic studies of OCD and disorders related to OCD, as well as for specific psychotherapeutic and psychopharmacologic interventions.

Original languageEnglish (US)
Pages (from-to)163-173
Number of pages11
JournalDepression and anxiety
Volume19
Issue number3
DOIs
StatePublished - 2004

Keywords

  • Anxiety disorders
  • Compulsions
  • Depression
  • Mood disorders
  • Obsessions

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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