Diagnostic criteria for primary neuronal degeneration of the Alzheimer's type.

C. Eisdorfer, D. Cohen

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


The diagnosis of patients presenting with memory or attentional deficits characteristic of dementia is a growing problem. Dementia may be symptomatic of a range of reversible medical and psychiatric conditions which appear to be indistinguishable from primary neuronal degeneration of the Alzheimer's type. While Alzheimer's disease is a neuropathological diagnosis, the importance of establishing a presumptive diagnosis which can be employed for investigational as well as clinical use is underscored. This paper proposes a diagnostic schema which reflects the current understanding of this disorder. There must be evidence of gradual progressive mental deterioration in attention, learning, memory, cognitive style, motivation, and higher order thinking. A comprehensive medical and psychiatric evaluation is obligatory to eliminate reversible physical illness, psychiatric disorder, or cerebrovascular condition as underlying causes of cognitive dysfunction.

Original languageEnglish (US)
Pages (from-to)553-557
Number of pages5
JournalJournal of Family Practice
Issue number4
StatePublished - Oct 1 1980

ASJC Scopus subject areas

  • Family Practice


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