Diagnostic accuracy of evoked potentials for functional impairment after contusive spinal cord injury in adult rats

Parthasarathy Thirumala, James Zhou, Rohan Krishnan, Nihita Manem, Shreya Umredkar, D. K. Hamilton, Jeffrey R. Balzer, Martin Oudega

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Iatrogenic spinal cord injury (SCI) is a cause of potentially debilitating post-operative neurologic complications. Currently, intra-operative neurophysiological monitoring (IONM) via somatosensory evoked potentials and motor-evoked potentials is used to detect and prevent impending SCI. However, no empirically validated interventions exist to halt the progression of iatrogenic SCI once it is detected. This is in part due to the lack of a suitable translational model that mimics the circumstances surrounding iatrogenic SCI detected via IONM. Here, we evaluate a model of simulated contusive iatrogenic SCI detected via IONM in adult female Sprague-Dawley rats. We show that transient losses of somatosensory evoked potentials responses are 88.24% sensitive (95% confidence interval [CI] 63.53-98.20) and 80% specific (95% CI 51.91-95.43) for significant functional impairment following simulated iatrogenic SCI. Similarly, we show that transient losses in motor-evoked potentials responses are 70.83% sensitive (95% CI 48.91-87.33) and 100% specific (95% CI 62.91-100.00) for significant functional impairment following simulated iatrogenic SCI. These results indicate that our model is a suitable replica of the circumstances surrounding clinical iatrogenic SCI.

Original languageEnglish (US)
Pages (from-to)122-126
Number of pages5
JournalJournal of Clinical Neuroscience
Volume25
DOIs
StatePublished - Mar 1 2016

Keywords

  • Iatrogenic
  • Injury
  • MEP
  • Neurophysiology
  • Spine
  • SSEP

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Diagnostic accuracy of evoked potentials for functional impairment after contusive spinal cord injury in adult rats'. Together they form a unique fingerprint.

Cite this