TY - JOUR
T1 - Diagnostic Ability of Fourier-Domain vs Time-Domain Optical Coherence Tomography for Glaucoma Detection
AU - Sehi, Mitra
AU - Grewal, Dilraj S.
AU - Sheets, Clinton W.
AU - Greenfield, David S.
N1 - Funding Information:
This study was supported in part by the Maltz Family Endowment for Glaucoma Research, Cleveland, Ohio; a grant from Mr. Barney Donnelley, Palm Beach, Florida; The Kessel Foundation, Bergenfield, New Jersey; Grant Nos. R01-EY08684, R01-EY013516, and P30-EY14801 from the National Institutes of Health, Bethesda, Maryland; and an unrestricted Grant from Research to Prevent Blindness Inc, New York, New York. Dr Greenfield has received research support and has served as a consultant for Carl Zeiss Meditec and Optovue Inc. Involved in design and conduct of study (M.S., Da.S.G.); collection of data (M.S., Di.S.G., C.W.S., Da.S.G.); management, analysis, and interpretation of data (M.S., Da.S.G.); and preparation, review, and approval of manuscript (M.S., Di.S.G., C.W.S., Da.S.G.). The study was approved by the Institutional Review Board for Human Research of the University of Miami Miller School of Medicine and was in agreement with the provisions of the Declaration of Helsinki.
PY - 2009/10
Y1 - 2009/10
N2 - Purpose: To compare retinal nerve fiber layer (RNFL) thickness assessments and the discriminating ability of Fourier-domain optical coherence tomography (FD-OCT) with that of time-domain optical coherence tomography (TD-OCT) for glaucoma detection. Design: Prospective, nonrandomized, observational cohort study. Methods: Normal and glaucomatous eyes underwent complete examination, standard automated perimetry, optic disc photography, TD-OCT (Stratus OCT; Carl Zeiss Meditec, Dublin, California, USA), and FD-OCT (RTVue; Optovue Inc, Fremont, California, USA). One eye per subject was enrolled. Two consecutive scans were acquired using a 3.46-mm diameter scan with TD-OCT and a 3.45-mm diameter scan with FD-OCT. For each of 5 RNFL parameters, the area under the receiver operator characteristic curve was calculated to compare the ability of FD-OCT and TD-OCT to discriminate between normal and glaucomatous eyes. Results: Fifty healthy persons (mean age, 65.3 ± 9.9 years) and 50 glaucoma patients (mean age, 67.7 ± 10.5 years) were enrolled. Average, superior, and inferior RNFL thickness measurements (in micrometers) were significantly (P < .01) greater with FD-OCT compared with TD-OCT in normal eyes (103.3 ± 12.6 vs 96.3 ± 10.7, 134.5 ± 18.6 vs 113.9 ± 16.3, and 129.7 ± 16.9 vs 125.5 ± 15.8, respectively) and glaucomatous eyes (P < .001; 77.6 ± 17.6 vs 70.4 ± 18.6, 108.0 ± 26.8 vs 86.8 ± 30.2, 82.2 ± 3.3 vs 73.5 ± 26.1, respectively). The area under the receiver operator characteristic curves for RNFL thickness were similar (P > .05) using FD-OCT (average, 0.88; superior, 0.80; inferior, 0.94) and TD-OCT (average, 0.87; superior, 0.79; inferior, 0.95). Conclusions: Cross-sectional peripapillary RNFL thickness measurements obtained using FD-OCT generated with the RTVue are greater than those obtained with TD-OCT and have similar diagnostic performance for glaucoma detection.
AB - Purpose: To compare retinal nerve fiber layer (RNFL) thickness assessments and the discriminating ability of Fourier-domain optical coherence tomography (FD-OCT) with that of time-domain optical coherence tomography (TD-OCT) for glaucoma detection. Design: Prospective, nonrandomized, observational cohort study. Methods: Normal and glaucomatous eyes underwent complete examination, standard automated perimetry, optic disc photography, TD-OCT (Stratus OCT; Carl Zeiss Meditec, Dublin, California, USA), and FD-OCT (RTVue; Optovue Inc, Fremont, California, USA). One eye per subject was enrolled. Two consecutive scans were acquired using a 3.46-mm diameter scan with TD-OCT and a 3.45-mm diameter scan with FD-OCT. For each of 5 RNFL parameters, the area under the receiver operator characteristic curve was calculated to compare the ability of FD-OCT and TD-OCT to discriminate between normal and glaucomatous eyes. Results: Fifty healthy persons (mean age, 65.3 ± 9.9 years) and 50 glaucoma patients (mean age, 67.7 ± 10.5 years) were enrolled. Average, superior, and inferior RNFL thickness measurements (in micrometers) were significantly (P < .01) greater with FD-OCT compared with TD-OCT in normal eyes (103.3 ± 12.6 vs 96.3 ± 10.7, 134.5 ± 18.6 vs 113.9 ± 16.3, and 129.7 ± 16.9 vs 125.5 ± 15.8, respectively) and glaucomatous eyes (P < .001; 77.6 ± 17.6 vs 70.4 ± 18.6, 108.0 ± 26.8 vs 86.8 ± 30.2, 82.2 ± 3.3 vs 73.5 ± 26.1, respectively). The area under the receiver operator characteristic curves for RNFL thickness were similar (P > .05) using FD-OCT (average, 0.88; superior, 0.80; inferior, 0.94) and TD-OCT (average, 0.87; superior, 0.79; inferior, 0.95). Conclusions: Cross-sectional peripapillary RNFL thickness measurements obtained using FD-OCT generated with the RTVue are greater than those obtained with TD-OCT and have similar diagnostic performance for glaucoma detection.
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U2 - 10.1016/j.ajo.2009.05.030
DO - 10.1016/j.ajo.2009.05.030
M3 - Article
C2 - 19589493
AN - SCOPUS:70349299846
VL - 148
SP - 597
EP - 605
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 4
ER -