Diagnosis of ocular surface lesions using ultra-high-resolution optical coherence tomography

Mohamed Abou Shousha, Carol Karp, Ana Paula Canto, Kelly Hodson, Patrick Oellers, Andrew A. Kao, Brett Bielory, Jared Matthews, Sander Dubovy, Victor L Perez Quinones, Jianhua Wang

Research output: Contribution to journalArticle

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Abstract

Purpose: To assess the use of ultra-high-resolution (UHR) optical coherence tomography (OCT) in the diagnosis of ocular surface lesions. Design: Prospective, noncomparative, interventional case series. Participants: Fifty-four eyes of 53 consecutive patients with biopsy-proven ocular surface lesions: 8 primary acquired melanosis lesions, 5 amelanotic melanoma lesions, 2 nevi, 19 ocular surface squamous neoplasia lesions, 1 histiocytosis lesion, 6 conjunctival lymphoma lesions, 2 conjunctival amyloidosis lesions, and 11 pterygia lesions. Intervention: Ultra-high-resolution OCT imaging of the ocular surface lesions. Main Outcome Measures: Clinical course and photographs, UHR OCT image, and histopathologic findings. Results: Ultra-high-resolution OCT images of all examined ocular surface lesions showed close correlation with the obtained histopathologic specimens. When clinical differential diagnosis of ocular surface lesions was broad, UHR OCT images provided optical signs indicating a more specific diagnosis and management. In cases of amelanotic melanoma, conjunctival amyloidosis, and primary histiocytosis and in 1 case of ocular surface squamous neoplasia, UHR OCT was instrumental in guiding the diagnosis. In those cases, UHR OCT suggested that the presumed clinical diagnosis was incorrect and favored a diagnosis that later was confirmed by histopathologic examination. Conclusions: Correlations between UHR OCT and histopathologic findings confirm that UHR OCT is an adjunctive diagnostic method that can provide a noninvasive means to help guide diagnosis and management of ocular surface lesions. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Original languageEnglish
Pages (from-to)883-891
Number of pages9
JournalOphthalmology
Volume120
Issue number5
DOIs
StatePublished - May 1 2013

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Optical Coherence Tomography
Amelanotic Melanoma
Histiocytosis
Pterygium
Melanosis
Nevus
Delayed Diagnosis
Disclosure
Amyloidosis
Lymphoma
Neoplasms
Differential Diagnosis
Outcome Assessment (Health Care)
Biopsy

ASJC Scopus subject areas

  • Ophthalmology

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Diagnosis of ocular surface lesions using ultra-high-resolution optical coherence tomography. / Abou Shousha, Mohamed; Karp, Carol; Canto, Ana Paula; Hodson, Kelly; Oellers, Patrick; Kao, Andrew A.; Bielory, Brett; Matthews, Jared; Dubovy, Sander; Perez Quinones, Victor L; Wang, Jianhua.

In: Ophthalmology, Vol. 120, No. 5, 01.05.2013, p. 883-891.

Research output: Contribution to journalArticle

Abou Shousha, M, Karp, C, Canto, AP, Hodson, K, Oellers, P, Kao, AA, Bielory, B, Matthews, J, Dubovy, S, Perez Quinones, VL & Wang, J 2013, 'Diagnosis of ocular surface lesions using ultra-high-resolution optical coherence tomography', Ophthalmology, vol. 120, no. 5, pp. 883-891. https://doi.org/10.1016/j.ophtha.2012.10.025
Abou Shousha, Mohamed ; Karp, Carol ; Canto, Ana Paula ; Hodson, Kelly ; Oellers, Patrick ; Kao, Andrew A. ; Bielory, Brett ; Matthews, Jared ; Dubovy, Sander ; Perez Quinones, Victor L ; Wang, Jianhua. / Diagnosis of ocular surface lesions using ultra-high-resolution optical coherence tomography. In: Ophthalmology. 2013 ; Vol. 120, No. 5. pp. 883-891.
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AU - Bielory, Brett

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N2 - Purpose: To assess the use of ultra-high-resolution (UHR) optical coherence tomography (OCT) in the diagnosis of ocular surface lesions. Design: Prospective, noncomparative, interventional case series. Participants: Fifty-four eyes of 53 consecutive patients with biopsy-proven ocular surface lesions: 8 primary acquired melanosis lesions, 5 amelanotic melanoma lesions, 2 nevi, 19 ocular surface squamous neoplasia lesions, 1 histiocytosis lesion, 6 conjunctival lymphoma lesions, 2 conjunctival amyloidosis lesions, and 11 pterygia lesions. Intervention: Ultra-high-resolution OCT imaging of the ocular surface lesions. Main Outcome Measures: Clinical course and photographs, UHR OCT image, and histopathologic findings. Results: Ultra-high-resolution OCT images of all examined ocular surface lesions showed close correlation with the obtained histopathologic specimens. When clinical differential diagnosis of ocular surface lesions was broad, UHR OCT images provided optical signs indicating a more specific diagnosis and management. In cases of amelanotic melanoma, conjunctival amyloidosis, and primary histiocytosis and in 1 case of ocular surface squamous neoplasia, UHR OCT was instrumental in guiding the diagnosis. In those cases, UHR OCT suggested that the presumed clinical diagnosis was incorrect and favored a diagnosis that later was confirmed by histopathologic examination. Conclusions: Correlations between UHR OCT and histopathologic findings confirm that UHR OCT is an adjunctive diagnostic method that can provide a noninvasive means to help guide diagnosis and management of ocular surface lesions. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

AB - Purpose: To assess the use of ultra-high-resolution (UHR) optical coherence tomography (OCT) in the diagnosis of ocular surface lesions. Design: Prospective, noncomparative, interventional case series. Participants: Fifty-four eyes of 53 consecutive patients with biopsy-proven ocular surface lesions: 8 primary acquired melanosis lesions, 5 amelanotic melanoma lesions, 2 nevi, 19 ocular surface squamous neoplasia lesions, 1 histiocytosis lesion, 6 conjunctival lymphoma lesions, 2 conjunctival amyloidosis lesions, and 11 pterygia lesions. Intervention: Ultra-high-resolution OCT imaging of the ocular surface lesions. Main Outcome Measures: Clinical course and photographs, UHR OCT image, and histopathologic findings. Results: Ultra-high-resolution OCT images of all examined ocular surface lesions showed close correlation with the obtained histopathologic specimens. When clinical differential diagnosis of ocular surface lesions was broad, UHR OCT images provided optical signs indicating a more specific diagnosis and management. In cases of amelanotic melanoma, conjunctival amyloidosis, and primary histiocytosis and in 1 case of ocular surface squamous neoplasia, UHR OCT was instrumental in guiding the diagnosis. In those cases, UHR OCT suggested that the presumed clinical diagnosis was incorrect and favored a diagnosis that later was confirmed by histopathologic examination. Conclusions: Correlations between UHR OCT and histopathologic findings confirm that UHR OCT is an adjunctive diagnostic method that can provide a noninvasive means to help guide diagnosis and management of ocular surface lesions. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

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