Diagnosis of intraocular lymphoma

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Purpose: To review current techniques for the diagnosis of intraocular lymphoma. Methods: Literature review. Results: There are a limited number of small case series and case reports reporting the diagnosis of intraocular lymphoma. Limitations in the ability to diagnose lymphoma through cytologic examination of the vitreous has led to investigations into immunohistochemistry either manually or by automated cytofluorography, intraocular cytokine determinations, and polymerase chain reaction of the vitreous or tissue lymphoid cells to detect gene rearrangements in the IgH, bcl-2, or T-cell receptor gamma gene. Data regarding diagnostic efficiency of the various testing strategies is limited by small patient numbers. Careful handling of the vitreous specimen and adequate laboratory and pathological support is critical. Conclusions: Despite a proliferation of new techniques for the diagnosis of intraocular lymphoma, none is clearly superior. Use of multiple testing strategies may improve diagnostic yield.

Original languageEnglish
Pages (from-to)7-16
Number of pages10
JournalOcular Immunology and Inflammation
Volume12
Issue number1
DOIs
StatePublished - Mar 1 2004

Fingerprint

Intraocular Lymphoma
T-Cell Receptor gamma Genes
Specimen Handling
Gene Rearrangement
Lymphoma
Immunohistochemistry
Lymphocytes
Cytokines
Polymerase Chain Reaction

Keywords

  • Cytology
  • Immunohistochemistry
  • Interleukin-10
  • Lymphoma
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Ophthalmology
  • Immunology and Allergy

Cite this

Diagnosis of intraocular lymphoma. / Davis, Janet L.

In: Ocular Immunology and Inflammation, Vol. 12, No. 1, 01.03.2004, p. 7-16.

Research output: Contribution to journalArticle

@article{91a2227481d74df992926a846dfcfebb,
title = "Diagnosis of intraocular lymphoma",
abstract = "Purpose: To review current techniques for the diagnosis of intraocular lymphoma. Methods: Literature review. Results: There are a limited number of small case series and case reports reporting the diagnosis of intraocular lymphoma. Limitations in the ability to diagnose lymphoma through cytologic examination of the vitreous has led to investigations into immunohistochemistry either manually or by automated cytofluorography, intraocular cytokine determinations, and polymerase chain reaction of the vitreous or tissue lymphoid cells to detect gene rearrangements in the IgH, bcl-2, or T-cell receptor gamma gene. Data regarding diagnostic efficiency of the various testing strategies is limited by small patient numbers. Careful handling of the vitreous specimen and adequate laboratory and pathological support is critical. Conclusions: Despite a proliferation of new techniques for the diagnosis of intraocular lymphoma, none is clearly superior. Use of multiple testing strategies may improve diagnostic yield.",
keywords = "Cytology, Immunohistochemistry, Interleukin-10, Lymphoma, Polymerase chain reaction",
author = "Davis, {Janet L}",
year = "2004",
month = "3",
day = "1",
doi = "10.1076/ocii.12.1.7.28072",
language = "English",
volume = "12",
pages = "7--16",
journal = "Ocular Immunology and Inflammation",
issn = "0927-3948",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Diagnosis of intraocular lymphoma

AU - Davis, Janet L

PY - 2004/3/1

Y1 - 2004/3/1

N2 - Purpose: To review current techniques for the diagnosis of intraocular lymphoma. Methods: Literature review. Results: There are a limited number of small case series and case reports reporting the diagnosis of intraocular lymphoma. Limitations in the ability to diagnose lymphoma through cytologic examination of the vitreous has led to investigations into immunohistochemistry either manually or by automated cytofluorography, intraocular cytokine determinations, and polymerase chain reaction of the vitreous or tissue lymphoid cells to detect gene rearrangements in the IgH, bcl-2, or T-cell receptor gamma gene. Data regarding diagnostic efficiency of the various testing strategies is limited by small patient numbers. Careful handling of the vitreous specimen and adequate laboratory and pathological support is critical. Conclusions: Despite a proliferation of new techniques for the diagnosis of intraocular lymphoma, none is clearly superior. Use of multiple testing strategies may improve diagnostic yield.

AB - Purpose: To review current techniques for the diagnosis of intraocular lymphoma. Methods: Literature review. Results: There are a limited number of small case series and case reports reporting the diagnosis of intraocular lymphoma. Limitations in the ability to diagnose lymphoma through cytologic examination of the vitreous has led to investigations into immunohistochemistry either manually or by automated cytofluorography, intraocular cytokine determinations, and polymerase chain reaction of the vitreous or tissue lymphoid cells to detect gene rearrangements in the IgH, bcl-2, or T-cell receptor gamma gene. Data regarding diagnostic efficiency of the various testing strategies is limited by small patient numbers. Careful handling of the vitreous specimen and adequate laboratory and pathological support is critical. Conclusions: Despite a proliferation of new techniques for the diagnosis of intraocular lymphoma, none is clearly superior. Use of multiple testing strategies may improve diagnostic yield.

KW - Cytology

KW - Immunohistochemistry

KW - Interleukin-10

KW - Lymphoma

KW - Polymerase chain reaction

UR - http://www.scopus.com/inward/record.url?scp=1642566071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642566071&partnerID=8YFLogxK

U2 - 10.1076/ocii.12.1.7.28072

DO - 10.1076/ocii.12.1.7.28072

M3 - Article

VL - 12

SP - 7

EP - 16

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

SN - 0927-3948

IS - 1

ER -