Diagnosis and treatment of diffuse large b-cell lymphoma in an orangutan (Pongo pygmaeus)

Offiong F. Ikpatt, Drury Reavill, Jason Chatfield, Susan Clubb, Joseph D. Rosenblatt, Glenn Fonte, Yao Shan Fan, Carolyn Cray

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Lymphoma is a common malignancy observed in companion animals. This type of naturally occurring neoplasia has been uncommonly reported in great apes. Diffuse large B-cell lymphoma was diagnosed in an 8-yr-old captive orangutan (Pongo pygmaeus) with gastrointestinal disease by histologic and immunohistochemical methodologies. The orangutan was treated with three cycles of combination chemotherapy (intravenous Rituxan, cyclophosphamide, doxorubicin, and vincristine). The primate has been in good health and exhibiting normal behaviors for more than 15 mo following treatment.

Original languageEnglish (US)
Pages (from-to)935-940
Number of pages6
JournalJournal of Zoo and Wildlife Medicine
Issue number4
StatePublished - Dec 1 2014


  • Immunohistochemistry
  • intestine
  • lymphoma
  • nonhuman primate
  • orangutan
  • Pongo pygmaeus

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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