Diagnosis and treatment of cytomegalovirus iridocyclitis without retinal necrosis

Schryver De Schryver, F. Rozenberg, N. Cassoux, S. Michelson, P. Kestelyn, P. LeHoang, Janet L Davis, Bahram Bodaghi

Research output: Contribution to journalArticle

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Abstract

Aim: To describe the diagnostic and therapeutic management of cytomegalovirus (CMV) anterior uveitis unassociated with retinal necrosis in immunocompetent patients. Methods: Patients referred between 2001 and 2003 for management of unilateral, chronic, recurrent uveitis associated with secondary glaucoma underwent extensive investigation including laboratory tests for herpes virus infections. Specific antiviral treatment was initiated in all cases and the level of ocular inflammation was evaluated during the follow up. Results: Five patients, three men and two women, were included. Median age was 50 years old (range 30-80 years). Anterior unilateral uveitis without iris atrophy was observed in all cases. Uveitis was chronic in three cases and recurrent in two cases. Glaucoma was observed in all patients with a median intraocular pressure of 30 mm Hg (range 22-43 mm Hg). Five patients responded initially to specific anti-CMV therapy. Even though glaucoma surgery was necessary in two cases, both ocular inflammation and glaucoma were controlled in all cases. Relapses occurred in three cases after cessation of therapy, requiring prolonged maintenance therapy with valganciclovir. Conclusions: CMV infection and specific antiviral therapy should be considered in all cases of relapsing or chronic iridocyclitis and secondary glaucoma. Maintenance regimens of valganciclovir may be necessary to prevent further relapses.

Original languageEnglish
Pages (from-to)852-855
Number of pages4
JournalBritish Journal of Ophthalmology
Volume90
Issue number7
DOIs
StatePublished - Jul 1 2006

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Iridocyclitis
Cytomegalovirus
Necrosis
Glaucoma
Anterior Uveitis
Uveitis
Antiviral Agents
Therapeutics
Inflammation
Recurrence
Cytomegalovirus Infections
Iris
Virus Diseases
Intraocular Pressure
Atrophy
Maintenance

ASJC Scopus subject areas

  • Ophthalmology

Cite this

De Schryver, S., Rozenberg, F., Cassoux, N., Michelson, S., Kestelyn, P., LeHoang, P., ... Bodaghi, B. (2006). Diagnosis and treatment of cytomegalovirus iridocyclitis without retinal necrosis. British Journal of Ophthalmology, 90(7), 852-855. https://doi.org/10.1136/bjo.2005.086546

Diagnosis and treatment of cytomegalovirus iridocyclitis without retinal necrosis. / De Schryver, Schryver; Rozenberg, F.; Cassoux, N.; Michelson, S.; Kestelyn, P.; LeHoang, P.; Davis, Janet L; Bodaghi, Bahram.

In: British Journal of Ophthalmology, Vol. 90, No. 7, 01.07.2006, p. 852-855.

Research output: Contribution to journalArticle

De Schryver, S, Rozenberg, F, Cassoux, N, Michelson, S, Kestelyn, P, LeHoang, P, Davis, JL & Bodaghi, B 2006, 'Diagnosis and treatment of cytomegalovirus iridocyclitis without retinal necrosis', British Journal of Ophthalmology, vol. 90, no. 7, pp. 852-855. https://doi.org/10.1136/bjo.2005.086546
De Schryver S, Rozenberg F, Cassoux N, Michelson S, Kestelyn P, LeHoang P et al. Diagnosis and treatment of cytomegalovirus iridocyclitis without retinal necrosis. British Journal of Ophthalmology. 2006 Jul 1;90(7):852-855. https://doi.org/10.1136/bjo.2005.086546
De Schryver, Schryver ; Rozenberg, F. ; Cassoux, N. ; Michelson, S. ; Kestelyn, P. ; LeHoang, P. ; Davis, Janet L ; Bodaghi, Bahram. / Diagnosis and treatment of cytomegalovirus iridocyclitis without retinal necrosis. In: British Journal of Ophthalmology. 2006 ; Vol. 90, No. 7. pp. 852-855.
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