Diagnosis and therapy of acute myeloid leukemia in the era of molecular risk stratification

Krishna V. Komanduri, Ross L. Levine

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The diagnosis and risk stratification of acute myeloid leukemia (AML) primarily rely on morphologic analysis and assessment of karyotype by chromosome banding analysis. For decades, standard AML induction therapy has utilized the combination of anthracyclines and cytarabine. Despite the use of postremission therapy, less than half of patients with AML will be cured of their disease. Allogeneic hematopoietic stem cell transplantation combines cytoreductive chemotherapy with adoptive immunotherapy and may cure patients who fail chemotherapy alone. Recent advances in next-generation sequencing have yielded important insights into the molecular landscape of AML with normal karyotype. Integrated prognostic models incorporating somatic mutation analyses may outperform prediction based on conventional clinical and cytogenetic factors alone. We review the evolution of risk profiling of AML from the cytogenetic to molecular era and describe the implications for AML diagnosis and postremission therapy.

Original languageEnglish (US)
Pages (from-to)59-72
Number of pages14
JournalAnnual review of medicine
Volume67
DOIs
StatePublished - Jan 14 2016

Keywords

  • Allogeneic hematopoietic stem cell transplantation
  • Graft-versus-leukemia
  • Induction chemotherapy
  • Next-generation sequencing
  • Postremission therapy
  • Somatic mutation profiling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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