Abstract
Objective: To examine the reliability and validity of the mCDR, a modified version of the clinical dementia rating (CDR) scale. Methods: The mCDR is an informant-based, technician-administered, structured interview with multiple choice responses, which does not include objective cognitive testing. Subjects (n=556) with no cognitive impairment (NCI), amnestic mild cognitive impairment (aMCI), and dementia were assessed with mCDR, CDR, and neuropsychological evaluation, while medial temporal atrophy (MTA) was measured on MRI scans. The mCDR and CDR were compared with respect to inter-rater reliability, validity, and ability to predict progression in cognitive diagnosis at 12 month follow-up. Results: The mCDR can be administered in less than one third of the time required to administer the CDR (30 min). Inter-rater reliability (Cohen's weighted κ) was 0.86 for the mCDR and 0.56 for the CDR. Ability to distinguish between NCI, aMCI, and Dementia subjects, and correlations to memory and nonmemory measures were marginally better for the CDR, in comparison to the mCDR. Correlations of mCDR and CDR scores to MTA scores did not differ. Baseline mCDR scores predicted transition from NCI to aMCI, whereas baseline CDR scores predicted transition from aMCI to Dementia. Conclusions: The mCDR, as compared to the CDR, is briefer and more reliable, and is a valid measure of functional ability among subjects with normal cognition, mild cognitive impairment, and mild dementia. The mCDR should be particularly useful as a reliable and economical instrument for assessing change in functional abilities, especially in multi-center clinical trials and population studies of MCI and mild dementia.
| Original language | English |
|---|---|
| Pages (from-to) | 282-289 |
| Number of pages | 8 |
| Journal | International Journal of Geriatric Psychiatry |
| Volume | 25 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2010 |
Fingerprint
Keywords
- Clinical rating scale
- Dementia
- Mild cognitive impairment
- MRI
- Visual rating
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Psychiatry and Mental health
Cite this
Diagnosis and staging of mild cognitive impairment, using a modification of the clinical dementia rating scale : The mCDR. / Duara, Ranjan; Loewenstein, David; Greig-Custo, Maria T.; Raj, Ashok; Barker, Warren; Potter, Elizabeth; Schofield, Elizabeth; Small, Brent; Schinka, John; Wu, Yougui; Potter, Huntington.
In: International Journal of Geriatric Psychiatry, Vol. 25, No. 3, 01.03.2010, p. 282-289.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diagnosis and staging of mild cognitive impairment, using a modification of the clinical dementia rating scale
T2 - The mCDR
AU - Duara, Ranjan
AU - Loewenstein, David
AU - Greig-Custo, Maria T.
AU - Raj, Ashok
AU - Barker, Warren
AU - Potter, Elizabeth
AU - Schofield, Elizabeth
AU - Small, Brent
AU - Schinka, John
AU - Wu, Yougui
AU - Potter, Huntington
PY - 2010/3/1
Y1 - 2010/3/1
N2 - Objective: To examine the reliability and validity of the mCDR, a modified version of the clinical dementia rating (CDR) scale. Methods: The mCDR is an informant-based, technician-administered, structured interview with multiple choice responses, which does not include objective cognitive testing. Subjects (n=556) with no cognitive impairment (NCI), amnestic mild cognitive impairment (aMCI), and dementia were assessed with mCDR, CDR, and neuropsychological evaluation, while medial temporal atrophy (MTA) was measured on MRI scans. The mCDR and CDR were compared with respect to inter-rater reliability, validity, and ability to predict progression in cognitive diagnosis at 12 month follow-up. Results: The mCDR can be administered in less than one third of the time required to administer the CDR (30 min). Inter-rater reliability (Cohen's weighted κ) was 0.86 for the mCDR and 0.56 for the CDR. Ability to distinguish between NCI, aMCI, and Dementia subjects, and correlations to memory and nonmemory measures were marginally better for the CDR, in comparison to the mCDR. Correlations of mCDR and CDR scores to MTA scores did not differ. Baseline mCDR scores predicted transition from NCI to aMCI, whereas baseline CDR scores predicted transition from aMCI to Dementia. Conclusions: The mCDR, as compared to the CDR, is briefer and more reliable, and is a valid measure of functional ability among subjects with normal cognition, mild cognitive impairment, and mild dementia. The mCDR should be particularly useful as a reliable and economical instrument for assessing change in functional abilities, especially in multi-center clinical trials and population studies of MCI and mild dementia.
AB - Objective: To examine the reliability and validity of the mCDR, a modified version of the clinical dementia rating (CDR) scale. Methods: The mCDR is an informant-based, technician-administered, structured interview with multiple choice responses, which does not include objective cognitive testing. Subjects (n=556) with no cognitive impairment (NCI), amnestic mild cognitive impairment (aMCI), and dementia were assessed with mCDR, CDR, and neuropsychological evaluation, while medial temporal atrophy (MTA) was measured on MRI scans. The mCDR and CDR were compared with respect to inter-rater reliability, validity, and ability to predict progression in cognitive diagnosis at 12 month follow-up. Results: The mCDR can be administered in less than one third of the time required to administer the CDR (30 min). Inter-rater reliability (Cohen's weighted κ) was 0.86 for the mCDR and 0.56 for the CDR. Ability to distinguish between NCI, aMCI, and Dementia subjects, and correlations to memory and nonmemory measures were marginally better for the CDR, in comparison to the mCDR. Correlations of mCDR and CDR scores to MTA scores did not differ. Baseline mCDR scores predicted transition from NCI to aMCI, whereas baseline CDR scores predicted transition from aMCI to Dementia. Conclusions: The mCDR, as compared to the CDR, is briefer and more reliable, and is a valid measure of functional ability among subjects with normal cognition, mild cognitive impairment, and mild dementia. The mCDR should be particularly useful as a reliable and economical instrument for assessing change in functional abilities, especially in multi-center clinical trials and population studies of MCI and mild dementia.
KW - Clinical rating scale
KW - Dementia
KW - Mild cognitive impairment
KW - MRI
KW - Visual rating
UR - http://www.scopus.com/inward/record.url?scp=76649131279&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=76649131279&partnerID=8YFLogxK
U2 - 10.1002/gps.2334
DO - 10.1002/gps.2334
M3 - Article
C2 - 19565573
AN - SCOPUS:76649131279
VL - 25
SP - 282
EP - 289
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
SN - 0885-6230
IS - 3
ER -