Abstract
Introduction: Topical chemotherapy has gained popularity among clinicians for the treatment of ocular surface squamous neoplasia (OSSN). The principal topical chemotherapy agents used in the management of OSSN are interferon-α2b, 5-fluorouracil, and mitomycin C. High-resolution optical coherence tomography (HR-OCT) is a non-invasive technique that can differentiate OSSN from other ocular surface lesions. Areas covered: This review highlights the current regimens and diagnostic modalities used in managing OSSN. A review of the literature was performed using the keywords ‘conjunctival intraepithelial neoplasia’, ‘ocular surface squamous neoplasia’, ‘optical coherence tomography’, ‘interferon-α2b’, ‘5-fluorouracil’ and ‘mitomycin C’. Expert commentary: Topical chemotherapy for OSSN can be used as primary therapy, for chemoreduction prior to surgical excision, and postoperatively to prevent tumor recurrence. It has the advantage of treating microscopic disease as well as large tumors. HR-OCT provides an ‘optical biopsy’ that can assist in diagnosis and guide management of OSSN lesions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11-19 |
| Number of pages | 9 |
| Journal | Expert Review of Ophthalmology |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2 2017 |
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Keywords
- 5-fluorouracil
- conjunctival neoplasia
- high resolution optical coherence tomography
- interferon-α2b
- mitomycin C
- Ocular surface squamous neoplasia
- topical chemotherapy
ASJC Scopus subject areas
- Biomedical Engineering
- Ophthalmology
- Optometry
Cite this
Diagnosis and medical management of ocular surface squamous neoplasia. / Sayed-Ahmed, Ibrahim O.; Palioura, Sotiria; Galor, Anat; Karp, Carol.
In: Expert Review of Ophthalmology, Vol. 12, No. 1, 02.01.2017, p. 11-19.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Diagnosis and medical management of ocular surface squamous neoplasia
AU - Sayed-Ahmed, Ibrahim O.
AU - Palioura, Sotiria
AU - Galor, Anat
AU - Karp, Carol
PY - 2017/1/2
Y1 - 2017/1/2
N2 - Introduction: Topical chemotherapy has gained popularity among clinicians for the treatment of ocular surface squamous neoplasia (OSSN). The principal topical chemotherapy agents used in the management of OSSN are interferon-α2b, 5-fluorouracil, and mitomycin C. High-resolution optical coherence tomography (HR-OCT) is a non-invasive technique that can differentiate OSSN from other ocular surface lesions. Areas covered: This review highlights the current regimens and diagnostic modalities used in managing OSSN. A review of the literature was performed using the keywords ‘conjunctival intraepithelial neoplasia’, ‘ocular surface squamous neoplasia’, ‘optical coherence tomography’, ‘interferon-α2b’, ‘5-fluorouracil’ and ‘mitomycin C’. Expert commentary: Topical chemotherapy for OSSN can be used as primary therapy, for chemoreduction prior to surgical excision, and postoperatively to prevent tumor recurrence. It has the advantage of treating microscopic disease as well as large tumors. HR-OCT provides an ‘optical biopsy’ that can assist in diagnosis and guide management of OSSN lesions.
AB - Introduction: Topical chemotherapy has gained popularity among clinicians for the treatment of ocular surface squamous neoplasia (OSSN). The principal topical chemotherapy agents used in the management of OSSN are interferon-α2b, 5-fluorouracil, and mitomycin C. High-resolution optical coherence tomography (HR-OCT) is a non-invasive technique that can differentiate OSSN from other ocular surface lesions. Areas covered: This review highlights the current regimens and diagnostic modalities used in managing OSSN. A review of the literature was performed using the keywords ‘conjunctival intraepithelial neoplasia’, ‘ocular surface squamous neoplasia’, ‘optical coherence tomography’, ‘interferon-α2b’, ‘5-fluorouracil’ and ‘mitomycin C’. Expert commentary: Topical chemotherapy for OSSN can be used as primary therapy, for chemoreduction prior to surgical excision, and postoperatively to prevent tumor recurrence. It has the advantage of treating microscopic disease as well as large tumors. HR-OCT provides an ‘optical biopsy’ that can assist in diagnosis and guide management of OSSN lesions.
KW - 5-fluorouracil
KW - conjunctival neoplasia
KW - high resolution optical coherence tomography
KW - interferon-α2b
KW - mitomycin C
KW - Ocular surface squamous neoplasia
KW - topical chemotherapy
UR - http://www.scopus.com/inward/record.url?scp=85007168374&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85007168374&partnerID=8YFLogxK
U2 - 10.1080/17469899.2017.1263567
DO - 10.1080/17469899.2017.1263567
M3 - Review article
AN - SCOPUS:85007168374
VL - 12
SP - 11
EP - 19
JO - Expert Review of Respiratory Medicine
JF - Expert Review of Respiratory Medicine
SN - 1747-6348
IS - 1
ER -