Diabetic vascular disease: It's all the RAGE

Barry I. Hudson, Thoralf Wendt, Loredana G. Bucciarelli, Ling Ling Rong, Yoshifumi Naka, Shi Fang Yan, Ann Marie Schmidt

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


The major consequence of long-term diabetes is the increased incidence of disease of the vasculature. Of the underlying mechanisms leading to disease, the accumulation of advanced glycation end products (AGEs), resulting from the associated hyperglycemia, is the most convincing. Interaction of AGEs with their receptor, RAGE, activates numerous signaling pathways leading to activation of proinflammatory and procoagulatory genes. Studies in rodent models of macro- and microvascular disease have demonstrated that blockade of RAGE can prevent development of disease. These observations highlight RAGE as a therapeutic target for treatment of diabetic vascular disease.

Original languageEnglish (US)
Pages (from-to)1588-1600
Number of pages13
JournalAntioxidants and Redox Signaling
Issue number11-12
StatePublished - Nov 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology


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