Diabetic vascular disease: It's all the RAGE

Barry Hudson, Thoralf Wendt, Loredana G. Bucciarelli, Ling Ling Rong, Yoshifumi Naka, Shi Fang Yan, Ann Marie Schmidt

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The major consequence of long-term diabetes is the increased incidence of disease of the vasculature. Of the underlying mechanisms leading to disease, the accumulation of advanced glycation end products (AGEs), resulting from the associated hyperglycemia, is the most convincing. Interaction of AGEs with their receptor, RAGE, activates numerous signaling pathways leading to activation of proinflammatory and procoagulatory genes. Studies in rodent models of macro- and microvascular disease have demonstrated that blockade of RAGE can prevent development of disease. These observations highlight RAGE as a therapeutic target for treatment of diabetic vascular disease.

Original languageEnglish
Pages (from-to)1588-1600
Number of pages13
JournalAntioxidants and Redox Signaling
Volume7
Issue number11-12
DOIs
StatePublished - Nov 1 2005
Externally publishedYes

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Diabetic Angiopathies
Advanced Glycosylation End Products
Hyperglycemia
Rodentia
Medical problems
Macros
Genes
Chemical activation
Incidence
Therapeutics

ASJC Scopus subject areas

  • Biochemistry

Cite this

Hudson, B., Wendt, T., Bucciarelli, L. G., Rong, L. L., Naka, Y., Yan, S. F., & Schmidt, A. M. (2005). Diabetic vascular disease: It's all the RAGE. Antioxidants and Redox Signaling, 7(11-12), 1588-1600. https://doi.org/10.1089/ars.2005.7.1588

Diabetic vascular disease : It's all the RAGE. / Hudson, Barry; Wendt, Thoralf; Bucciarelli, Loredana G.; Rong, Ling Ling; Naka, Yoshifumi; Yan, Shi Fang; Schmidt, Ann Marie.

In: Antioxidants and Redox Signaling, Vol. 7, No. 11-12, 01.11.2005, p. 1588-1600.

Research output: Contribution to journalArticle

Hudson, B, Wendt, T, Bucciarelli, LG, Rong, LL, Naka, Y, Yan, SF & Schmidt, AM 2005, 'Diabetic vascular disease: It's all the RAGE', Antioxidants and Redox Signaling, vol. 7, no. 11-12, pp. 1588-1600. https://doi.org/10.1089/ars.2005.7.1588
Hudson B, Wendt T, Bucciarelli LG, Rong LL, Naka Y, Yan SF et al. Diabetic vascular disease: It's all the RAGE. Antioxidants and Redox Signaling. 2005 Nov 1;7(11-12):1588-1600. https://doi.org/10.1089/ars.2005.7.1588
Hudson, Barry ; Wendt, Thoralf ; Bucciarelli, Loredana G. ; Rong, Ling Ling ; Naka, Yoshifumi ; Yan, Shi Fang ; Schmidt, Ann Marie. / Diabetic vascular disease : It's all the RAGE. In: Antioxidants and Redox Signaling. 2005 ; Vol. 7, No. 11-12. pp. 1588-1600.
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