TY - JOUR
T1 - Diabetic peripheral neuropathic pain
T2 - Clinical and quality-of-life issues
AU - Argoff, Charles E.
AU - Cole, B. Eliot
AU - Fishbain, David A.
AU - Irving, Gordon A.
N1 - Funding Information:
Dr Argoff receives grant and research support from Endo Pharmaceuticals, UCB Pharma, and Cephalon, Inc. He is a consultant to GlaxoWellcome, Eli Lilly and Company, Endo Pharmaceuticals, Pfizer Inc, UCB Pharma, and Allergan. Dr Cole receives honoraria from Eli Lilly and Company and Ligand Pharmaceuticals Inc. Dr Fishbain receives honoraria from Eli Lilly and Company and Endo Pharmaceuticals. Dr Irving receives grant and research support from Celgene Corporation and is a consultant to Pfizer Inc, Eli Lilly and Company, and Depomed, Inc. He also receives honoraria from Eli Lilly and Company and Pfizer Inc. SUPPLEMENT ARTICLE
PY - 2006/4
Y1 - 2006/4
N2 - Diabetic peripheral neuropathy (DPN) is estimated to be present In 50% of people living with diabetes mellitus (DM). Comorbidities of DM, such as macrovascular and microvascular changes, also Interact with DPN and affect Its course. In patients with DM, DPN is the leading causa of foot ulcers, which In turn are a major cause of amputation In the United States. Although most patients with DPN do not have pain, approximately 11.% of patients with DPN have chronic, painful symptoms that diminish quality of life, disrupt sleep, and can lead to depression. Despite the number of patients affected by DPN pain, little consensus exists about the pathophysiology, best diagnostic tools, and primary treatment choices. This article reviews the current knowledge about and presents recommendations for diagnostic assessment of DPN pain based on a review of the literature.
AB - Diabetic peripheral neuropathy (DPN) is estimated to be present In 50% of people living with diabetes mellitus (DM). Comorbidities of DM, such as macrovascular and microvascular changes, also Interact with DPN and affect Its course. In patients with DM, DPN is the leading causa of foot ulcers, which In turn are a major cause of amputation In the United States. Although most patients with DPN do not have pain, approximately 11.% of patients with DPN have chronic, painful symptoms that diminish quality of life, disrupt sleep, and can lead to depression. Despite the number of patients affected by DPN pain, little consensus exists about the pathophysiology, best diagnostic tools, and primary treatment choices. This article reviews the current knowledge about and presents recommendations for diagnostic assessment of DPN pain based on a review of the literature.
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U2 - 10.1016/s0025-6196(11)61474-2
DO - 10.1016/s0025-6196(11)61474-2
M3 - Review article
C2 - 16608048
AN - SCOPUS:33645657561
VL - 81
SP - S3
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
SN - 0025-6196
IS - 4 SUPPL.
ER -