Diabetic muscle infarction after simultaneous pancreas-kidney transplant

Spiros Delis, Gaetano Ciancio, Javier Casillas, Jose Figueiro, Alvaro Garcia, Joshua Miller, George W. Burke

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Diabetic muscle infarction (DMI) is a rare entity that occurs in patients with long-standing type 1 insulin dependent diabetes mellitus (IDDM). We describe DMI occurring on an average of 5 months after SPK in four patients with IDDM and end stage renal disease (ESRD). These patients had evidence of other long-term diabetic complications including retinopathy and neuropathy, as well as microangiopathy and hypercoagulability, both of which are pre-disposing factors for DMI. The etiology of DMI is not well understood. Despite establishment of normoglycemia after kidney-pancreas transplantation, DMI may occur as a result of tissue damage/fragility secondary to the pre-existing long-term labile glycemic control and hypertension. This may be exacerbated by the pro-coagulant effects of the calcineurin-inhibitors and the use of steroids as part of the immunosuppressive regimen.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalClinical Transplantation
Volume16
Issue number4
DOIs
StatePublished - Jan 1 2002

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Keywords

  • Diabetic muscle infarction
  • Kidney tranplant
  • Simultaneous pancreas

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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