Diabetic foot ulcers: Effects of hyperoxia and stromal-derived factor-1α on endothelial progenitor cells

Ying Zhuge, Sharyce Gonzalez, Omaida C Velazquez

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In order for cutaneous wounds to heal in a timely manner, many requisites must be fulfilled, including infection control, resolution of inflammation, proper cell migration, differentiation, proliferation, deposition of extracellular matrix (ECM), sufficient delivery of oxygen and nutrients, wound contraction, and reepithelialization (Lazarus et al. Arch Dermatol 130: 489-93, 1994). These events in turn require proper immune status, active angiogenesis/vasculogenesis, and avoidance of negative mechanical forces, such as weight bearing (Liu and Velazquez Antioxid Redox Signal 10:1869-82, 2008). Of all the above conditions, the most critical component for normal healing of full-thickness wounds is the formation of new blood vessels within the granulation tissue.

Original languageEnglish (US)
Title of host publicationThe Diabetic Foot
Subtitle of host publicationMedical and Surgical Management: Third Edition
PublisherHumana Press Inc.
Pages217-229
Number of pages13
ISBN (Electronic)9781617797910
ISBN (Print)9781617797903
DOIs
StatePublished - Jan 1 2012

Keywords

  • Diabetic foot ulcers
  • Endothelial progenitor cells
  • HBO
  • Hyperoxia
  • Stromal-derived growth factor-1α

ASJC Scopus subject areas

  • Medicine(all)

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