Diabetic foot ulcers: Effects of hyperoxia and SDF-1α on endothelial progenitor cells

Ying Zhuge, Zhao-Jun Liu, Bianca Habib, Omaida C Velazquez

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Diabetes mellitus is a common disease afflicting many people. In addition to coronary artery disease, diabetic retinopathy and renal failure, diabetic patients face abnormal wound healing and have increased lower extremity ulcers and amputations. In diabetes, wound healing is altered due to both macrovascular and microvascular processes. While the former can be addressed with surgical intervention, the latter is more difficult to correct. Neovascularization within the granulation tissue via angiogenesis and vasculogenesis is critical for wound healing. Endothelial progenitor cells (EPCs) have been implicated in vasculogenesis. Mobilization of EPCs from the bone marrow is impaired in diabetes and homing of EPCs to the wound is also abnormal. Recent studies show that hyperoxia and administration of exogenous stromal-derived factor-1α increases circulatory and wound levels of EPCs and improves wound healing in diabetic mice. These findings have great potential for translation into human counterparts as the treatment for this prevalent disease matures.

Original languageEnglish
Pages (from-to)113-125
Number of pages13
JournalExpert Review of Endocrinology and Metabolism
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2010

Fingerprint

Hyperoxia
Diabetic Foot
Wound Healing
Granulation Tissue
Wounds and Injuries
Diabetic Retinopathy
Amputation
Ulcer
Renal Insufficiency
Coronary Artery Disease
Lower Extremity
Diabetes Mellitus
Bone Marrow
Endothelial Progenitor Cells
Therapeutics

Keywords

  • Diabetic ulcer
  • Endothelial progenitor cell
  • Hyperoxia
  • Stromal-derived growth factor-1α

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Diabetic foot ulcers : Effects of hyperoxia and SDF-1α on endothelial progenitor cells. / Zhuge, Ying; Liu, Zhao-Jun; Habib, Bianca; Velazquez, Omaida C.

In: Expert Review of Endocrinology and Metabolism, Vol. 5, No. 1, 01.01.2010, p. 113-125.

Research output: Contribution to journalArticle

@article{50373b53e0b3488fa8237ae543f5f330,
title = "Diabetic foot ulcers: Effects of hyperoxia and SDF-1α on endothelial progenitor cells",
abstract = "Diabetes mellitus is a common disease afflicting many people. In addition to coronary artery disease, diabetic retinopathy and renal failure, diabetic patients face abnormal wound healing and have increased lower extremity ulcers and amputations. In diabetes, wound healing is altered due to both macrovascular and microvascular processes. While the former can be addressed with surgical intervention, the latter is more difficult to correct. Neovascularization within the granulation tissue via angiogenesis and vasculogenesis is critical for wound healing. Endothelial progenitor cells (EPCs) have been implicated in vasculogenesis. Mobilization of EPCs from the bone marrow is impaired in diabetes and homing of EPCs to the wound is also abnormal. Recent studies show that hyperoxia and administration of exogenous stromal-derived factor-1α increases circulatory and wound levels of EPCs and improves wound healing in diabetic mice. These findings have great potential for translation into human counterparts as the treatment for this prevalent disease matures.",
keywords = "Diabetic ulcer, Endothelial progenitor cell, Hyperoxia, Stromal-derived growth factor-1α",
author = "Ying Zhuge and Zhao-Jun Liu and Bianca Habib and Velazquez, {Omaida C}",
year = "2010",
month = "1",
day = "1",
doi = "10.1586/eem.09.61",
language = "English",
volume = "5",
pages = "113--125",
journal = "Expert Review of Endocrinology and Metabolism",
issn = "1744-6651",
publisher = "Expert Reviews Ltd.",
number = "1",

}

TY - JOUR

T1 - Diabetic foot ulcers

T2 - Effects of hyperoxia and SDF-1α on endothelial progenitor cells

AU - Zhuge, Ying

AU - Liu, Zhao-Jun

AU - Habib, Bianca

AU - Velazquez, Omaida C

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Diabetes mellitus is a common disease afflicting many people. In addition to coronary artery disease, diabetic retinopathy and renal failure, diabetic patients face abnormal wound healing and have increased lower extremity ulcers and amputations. In diabetes, wound healing is altered due to both macrovascular and microvascular processes. While the former can be addressed with surgical intervention, the latter is more difficult to correct. Neovascularization within the granulation tissue via angiogenesis and vasculogenesis is critical for wound healing. Endothelial progenitor cells (EPCs) have been implicated in vasculogenesis. Mobilization of EPCs from the bone marrow is impaired in diabetes and homing of EPCs to the wound is also abnormal. Recent studies show that hyperoxia and administration of exogenous stromal-derived factor-1α increases circulatory and wound levels of EPCs and improves wound healing in diabetic mice. These findings have great potential for translation into human counterparts as the treatment for this prevalent disease matures.

AB - Diabetes mellitus is a common disease afflicting many people. In addition to coronary artery disease, diabetic retinopathy and renal failure, diabetic patients face abnormal wound healing and have increased lower extremity ulcers and amputations. In diabetes, wound healing is altered due to both macrovascular and microvascular processes. While the former can be addressed with surgical intervention, the latter is more difficult to correct. Neovascularization within the granulation tissue via angiogenesis and vasculogenesis is critical for wound healing. Endothelial progenitor cells (EPCs) have been implicated in vasculogenesis. Mobilization of EPCs from the bone marrow is impaired in diabetes and homing of EPCs to the wound is also abnormal. Recent studies show that hyperoxia and administration of exogenous stromal-derived factor-1α increases circulatory and wound levels of EPCs and improves wound healing in diabetic mice. These findings have great potential for translation into human counterparts as the treatment for this prevalent disease matures.

KW - Diabetic ulcer

KW - Endothelial progenitor cell

KW - Hyperoxia

KW - Stromal-derived growth factor-1α

UR - http://www.scopus.com/inward/record.url?scp=77949805144&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949805144&partnerID=8YFLogxK

U2 - 10.1586/eem.09.61

DO - 10.1586/eem.09.61

M3 - Article

AN - SCOPUS:77949805144

VL - 5

SP - 113

EP - 125

JO - Expert Review of Endocrinology and Metabolism

JF - Expert Review of Endocrinology and Metabolism

SN - 1744-6651

IS - 1

ER -