Diabetic cardiomyopathy: Pathophysiological and clinical aspects

P. Gargiulo, G. Jacobellis, V. Vaccari, D. Andreani

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Several studies have suggested the existence of a diabetic cardiomyopathy independent of coronary vascular sclerosis and hypertension. The condition is often without symptoms and/or with slight signs of anatomical and functional abnormalities. The pathogenetic mechanisms involved are various and not all completely understood. Metabolic abnormalities in glucose transport and lipid metabolism alterated calcium and potassium homeostasis, microangiopathy with microaneurisms and microthrombi, cardiomyocytes hyperthrophy, structural collagen alterations, interstitial and perivascular fibrosis and deficit in serin-protease inhibitors have been described as frequent and partly specific features of diabetic cardiomyopathy. Echocardiography has demonstrated the presence of a diastolic dysfunction, as the earliest sign of diabetic cardiomyopathy. Slight left ventricular hypertrophy with impaired left ventricular filling and relaxation has been described. Systolic function is normal or even increased at rest, but usually decreased during heavy exercise. In conclusion, according to these findings, diabetic cardiomyopathy seems to be a rather early complication, although frequently latent, but independent of other clinical conditions involving the heart in diabetes.

Original languageEnglish (US)
Pages (from-to)336-346
Number of pages11
JournalDiabetes, Nutrition and Metabolism - Clinical and Experimental
Issue number6
StatePublished - Dec 1 1998
Externally publishedYes


  • Cardiomyopathy
  • Diabetes mellitus
  • Diabetic myocytes damage
  • Diastolic dysfunction
  • Systolic dysfunction

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine (miscellaneous)
  • Food Science
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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