Diabetic aggravation of stroke and animal models

Ashish K. Rehni, Allen Liu, Miguel A. Perez-Pinzon, Kunjan R. Dave

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Cerebral ischemia in diabetics results in severe brain damage. Different animal models of cerebral ischemia have been used to study the aggravation of ischemic brain damage in the diabetic condition. Since different disease conditions such as diabetes differently affect outcome following cerebral ischemia, the Stroke Therapy Academic Industry Roundtable (STAIR) guidelines recommends use of diseased animals for evaluating neuroprotective therapies targeted to reduce cerebral ischemic damage. The goal of this review is to discuss the technicalities and pros/cons of various animal models of cerebral ischemia currently being employed to study diabetes-related ischemic brain damage. The rational use of such animal systems in studying the disease condition may better help evaluate novel therapeutic approaches for diabetes related exacerbation of ischemic brain damage.

Original languageEnglish (US)
Pages (from-to)63-79
Number of pages17
JournalExperimental neurology
Volume292
DOIs
StatePublished - Jun 1 2017

Keywords

  • Focal cerebral ischemia
  • Global cerebral ischemia
  • Hemorrhage
  • Preclinical models
  • Stroke
  • Translational research
  • White matter damage

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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