Dexamethasone suppression test identifies a subset of elderly depressed patients with reduced platelet serotonin transport and resistance to imipramine inhibition of transport

T. A. Slotkin, J. C. Hays, Charles Nemeroff, B. J. Carroll

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Dysregulation of the hypothalamus-pituitary-adrenal axis (HPA) is more common in elderly patients with depression than in younger depressed patients, and glucocorticoids are known to influence serotonergic function. Elderly depressed patients are also reportedly more resistant to therapeutic effects of antidepressants. In the current study, we measured platelet serotonin transporter binding sites and transport function in young and elderly depressed patients and determined the relationship to HPA status as assessed with the dexamethasone suppression test (DST). The density and affinity of transporter molecules showed no differences between young and elderly depressed patients, regardless of DST results. Nevertheless, transporter function showed a substantial interaction of aging with DST: elderly DST suppressors showed a deficit in [3H]serotonin uptake capabilities and resistance to imipramine inhibition of uptake. No such defects were seen in the young depressed cohort, regardless of DST status, nor in elderly depressed DST non-suppressors. These results are consistent with the view that depression in the elderly exhibits basic biological differences from depression in earlier life, and that such distinctions may account in part for therapeutic ineffectiveness of antidepressants in specific subgroups, associated with the presence or absence of appropriate HPA regulation.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalDepression and Anxiety
Volume6
Issue number1
DOIs
StatePublished - Dec 1 1997
Externally publishedYes

Fingerprint

Imipramine
Dexamethasone
Serotonin
Blood Platelets
Hypothalamus
Antidepressive Agents
Serotonin Plasma Membrane Transport Proteins
Therapeutic Uses
Glucocorticoids
Binding Sites

Keywords

  • Aging
  • Depression
  • Imipramine
  • Platelet serotonin transporter function in depression
  • Tricyclic antidepressants

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

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