Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice

Raffaella Poggioli, Cintia B. Ueta, Rafael Arrojo E Drigo, Melany Castillo, Tatiana L. Fonseca, Antonio C. Bianco

Research output: Contribution to journalArticle

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Abstract

Objective To investigate how long-term treatment with dexamethasone affects energy expenditure and adiposity in mice and whether this is influenced by feeding on a high-fat diet (HFD). Design and Methods Mice were placed on a HFD for 2 weeks and started on dexamethasone at 5 mg/kg every other day during the next 7 weeks. Results Treatment with dexamethasone increased body fat, an effect that was more pronounced in the animals kept on HFD; dexamethasone treatment also worsened liver steatosis caused by the HFD. At the same time, treatment with dexamethasone lowered the respiratory quotient in chow-fed animals and slowed nightly metabolic rate in the animals kept on HFD. In addition, the acute VO2 acceleration in response to β3 adrenergic-stimulation was significantly limited in the dexamethasone-treated animals, as a result of marked decrease in UCP-1 mRNA observed in the brown adipose tissue of these animals. Conclusions Long-term treatment with dexamethasone in a mouse model of diet-induced obesity decreases brown adipose tissue thermogenesis and exaggerates adiposity and liver steatosis. © 2013 American Institute of Chemical Engineers AIChE J, 2013

Original languageEnglish
JournalObesity
Volume21
Issue number9
DOIs
StatePublished - Sep 1 2013

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Energy Metabolism
Dexamethasone
Obesity
High Fat Diet
Diet
Brown Adipose Tissue
Adiposity
Fatty Liver
Thermogenesis
Adrenergic Agents
Adipose Tissue
Messenger RNA

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Poggioli, R., Ueta, C. B., Drigo, R. A. E., Castillo, M., Fonseca, T. L., & Bianco, A. C. (2013). Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice. Obesity, 21(9). https://doi.org/10.1002/oby.20338

Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice. / Poggioli, Raffaella; Ueta, Cintia B.; Drigo, Rafael Arrojo E; Castillo, Melany; Fonseca, Tatiana L.; Bianco, Antonio C.

In: Obesity, Vol. 21, No. 9, 01.09.2013.

Research output: Contribution to journalArticle

Poggioli, R, Ueta, CB, Drigo, RAE, Castillo, M, Fonseca, TL & Bianco, AC 2013, 'Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice', Obesity, vol. 21, no. 9. https://doi.org/10.1002/oby.20338
Poggioli, Raffaella ; Ueta, Cintia B. ; Drigo, Rafael Arrojo E ; Castillo, Melany ; Fonseca, Tatiana L. ; Bianco, Antonio C. / Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice. In: Obesity. 2013 ; Vol. 21, No. 9.
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