Developmental expression of the oligodendrocyte myelin glycoprotein in the mouse telencephalon

Vanessa Gil, Zoe Bichler, Jae K. Lee, Oscar Seira, Franc Llorens, Ana Bribian, Ricardo Morales, Enric Claverol-Tinture, Eduardo Soriano, Lauro Sumoy, Binhai Zheng, Jose A. Del Río

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The oligodendrocyte myelin glycoprotein is a glycosylphosphatidylinositol- anchored protein expressed by neurons and oligodendrocytes in the central nervous system. Attempts have been made to identify the functions of the myelin-associated inhibitory proteins (MAIPs) after axonal lesion or in neurodegeneration. However, the developmental roles of some of these proteins and their receptors remain elusive. Recent studies indicate that NgR1 and the recently discovered receptor PirB restrict cortical synaptic plasticity. However, the putative factors that trigger these effects are unknown. Because Nogo-A is mostly associated with the endoplasmic reticulum and myelin associated glycoprotein appears late during development, the putative participation of OMgp should be considered. Here, we examine the pattern of development of OMgp immunoreactive elements during mouse telencephalic development. OMgp immunoreactivity in the developing cortex follows the establishment of the thalamo-cortical barrel field. At the cellular level, we located OMgp neuronal membranes in dendrites and axons as well as in brain synaptosome fractions and axon varicosities. Lastly, the analysis of the barrel field in OMgp-deficient mice revealed that although thalamo-cortical connections were formed, their targeting in layer IV was altered, and numerous axons ectopically invaded layers II-III. Our data support the idea that early expressed MAIPs play an active role during development and point to OMgp participating in thalamo-cortical connections. The Author

Original languageEnglish (US)
Pages (from-to)1769-1779
Number of pages11
JournalCerebral Cortex
Volume20
Issue number8
DOIs
StatePublished - Aug 2010

Keywords

  • axon plasticity
  • barrel-field specification
  • cortical lamination
  • myelin

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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    Gil, V., Bichler, Z., Lee, J. K., Seira, O., Llorens, F., Bribian, A., Morales, R., Claverol-Tinture, E., Soriano, E., Sumoy, L., Zheng, B., & Del Río, J. A. (2010). Developmental expression of the oligodendrocyte myelin glycoprotein in the mouse telencephalon. Cerebral Cortex, 20(8), 1769-1779. https://doi.org/10.1093/cercor/bhp246