Development of ultrasound tomography for breast imaging: Technical assessment

Nebojsa Duric, Peter Littrup, Alex Babkin, David Chambers, Stephen Azevedo, Arkady Kalinin, Roman Pevzner, Mikhail Tokarev, Earle Holsapple, Olsi Rama, Robert Duncan

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

Ultrasound imaging is widely used in medicine because of its benign characteristics and real-time capabilities. Physics theory suggests that the application of tomographic techniques may allow ultrasound imaging to reach its full potential as a diagnostic tool allowing it to compete with other tomographic modalities such as x-ray computer tomography, and MRI. This paper describes the construction and use of a prototype tomographic scanner and reports on the feasibility of implementing tomographic theory in practice and the potential of ultrasound (US) tomography in diagnostic imaging. Data were collected with the prototype by scanning two types of phantoms and a cadaveric breast. A specialized suite of algorithms was developed and utilized to construct images of reflectivity and sound speed from the phantom data. The basic results can be summarized as follows. (i) A fast, clinically relevant US tomography scanner can be built using existing technology. (ii) The spatial resolution, deduced from images of reflectivity, is 0.4 mm. The demonstrated 10 cm depth-of-field is superior to that of conventional ultrasound and the image contrast is improved through the reduction of speckle noise and overall lowering of the noise floor. (iii) Images of acoustic properties such as sound speed suggest that it is possible to measure variations in the sound speed of 5 m/s. An apparent correlation with x-ray attenuation suggests that the sound speed can be used to discriminate between various types of soft tissue. (iv) Ultrasound tomography has the potential to improve diagnostic imaging in relation to breast cancer detection.

Original languageEnglish (US)
Pages (from-to)1375-1386
Number of pages12
JournalMedical physics
Volume32
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

Keywords

  • Breast cancer
  • Diagnostic imaging
  • Tissue characterization
  • Ultrasound tomography

ASJC Scopus subject areas

  • Biophysics

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    Duric, N., Littrup, P., Babkin, A., Chambers, D., Azevedo, S., Kalinin, A., Pevzner, R., Tokarev, M., Holsapple, E., Rama, O., & Duncan, R. (2005). Development of ultrasound tomography for breast imaging: Technical assessment. Medical physics, 32(5), 1375-1386. https://doi.org/10.1118/1.1897463