TY - JOUR
T1 - Development of polycythemia vera and chronic lymphocytic leukemia during the course of refractory idiopathic thrombocytopenic purpura
AU - Wang, Grace
AU - Ahn, Yeon S.
AU - Whitcomb, Clarence C.
AU - Harrington, William J.
PY - 1984/4/15
Y1 - 1984/4/15
N2 - A case in which polycythemia vera and chronic lymphocytic leukemia (CLL) developed during the course of idiopathic thrombocytopenic purpura (ITP) is described. Observations in this case suggest that ITP was a premonitor of the clinical development of CLL and preceded the manifestation of polycythemia vera. The polycythemia was mild, requiring infrequent phlebotomies, and, as the CLL progressed, the requirement for phlebotomy diminished. Evidence of both CLL and myeloid proliferation, as well as severe immune thrombocytopenia, persisted throughout her course. Studies on lymphocytes revealed characteristics of those of CLL. Excellent therapeutic response of the CLL was observed with the use of vinblastine and steroids.
AB - A case in which polycythemia vera and chronic lymphocytic leukemia (CLL) developed during the course of idiopathic thrombocytopenic purpura (ITP) is described. Observations in this case suggest that ITP was a premonitor of the clinical development of CLL and preceded the manifestation of polycythemia vera. The polycythemia was mild, requiring infrequent phlebotomies, and, as the CLL progressed, the requirement for phlebotomy diminished. Evidence of both CLL and myeloid proliferation, as well as severe immune thrombocytopenia, persisted throughout her course. Studies on lymphocytes revealed characteristics of those of CLL. Excellent therapeutic response of the CLL was observed with the use of vinblastine and steroids.
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U2 - 10.1002/1097-0142(19840415)53:8<1770::AID-CNCR2820530827>3.0.CO;2-V
DO - 10.1002/1097-0142(19840415)53:8<1770::AID-CNCR2820530827>3.0.CO;2-V
M3 - Article
C2 - 6365308
AN - SCOPUS:0021220677
VL - 53
SP - 1770
EP - 1776
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 8
ER -