Development of polycythemia vera and chronic lymphocytic leukemia during the course of refractory idiopathic thrombocytopenic purpura

Grace Wang, Yeon S. Ahn, Clarence C. Whitcomb, William J. Harrington

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A case in which polycythemia vera and chronic lymphocytic leukemia (CLL) developed during the course of idiopathic thrombocytopenic purpura (ITP) is described. Observations in this case suggest that ITP was a premonitor of the clinical development of CLL and preceded the manifestation of polycythemia vera. The polycythemia was mild, requiring infrequent phlebotomies, and, as the CLL progressed, the requirement for phlebotomy diminished. Evidence of both CLL and myeloid proliferation, as well as severe immune thrombocytopenia, persisted throughout her course. Studies on lymphocytes revealed characteristics of those of CLL. Excellent therapeutic response of the CLL was observed with the use of vinblastine and steroids.

Original languageEnglish (US)
Pages (from-to)1770-1776
Number of pages7
JournalCancer
Volume53
Issue number8
DOIs
StatePublished - Apr 15 1984

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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