Development of neonatal Th1/Th2 function

Becky Adkins

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

Newborn animals generally mount poor T cell-mediated immune responses in vivo. As a result, neonates fall prey to infectious agents and diseases which have little impact on immunocompetent adult animals. For some time, it was believed that this phenomenon was due to an intrinsic inability of newborns to mount developmentally mature Th1 responses. Recent studies in mice have challenged that view; under certain conditions, adult-level Th1 function has been achieved in newborns. More often, however, neonates develop Th2-dominant responses. A major challenge in the field of developmental immunology is to understand why the 'default' response for neonates is Th2 function. Cell intrinsic as well as environmental influences may contribute to Th2 skewing in neonates.

Original languageEnglish (US)
Pages (from-to)157-171
Number of pages15
JournalInternational reviews of immunology
Volume19
Issue number2-3
DOIs
StatePublished - Jan 1 2000

Keywords

  • Immunological memory
  • Neonatal
  • Th1/Th2
  • Tolerance
  • Vaccine

ASJC Scopus subject areas

  • Immunology

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