Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain

Asahi Tomitaka, Hamed Arami, Andrea Raymond, Adriana Yndart, Ajeet Kaushik, Rahul Dev Jayant, Yasushi Takemura, Yong Cai, Michal J Toborek, Madhavan Nair

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26 Scopus citations

Abstract

Magneto-plasmonic nanoparticles are one of the emerging multi-functional materials in the field of nanomedicine. Their potential for targeting and multi-modal imaging is highly attractive. In this study, magnetic core/gold shell (MNP@Au) magneto-plasmonic nanoparticles were synthesized by citrate reduction of Au ions on magnetic nanoparticle seeds. Hydrodynamic size and optical properties of magneto-plasmonic nanoparticles synthesized with the variation of Au ions and reducing agent concentrations were evaluated. The synthesized magneto-plasmonic nanoparticles exhibited superparamagnetic properties, and their magnetic properties contributed to the concentration-dependent contrast in magnetic resonance imaging (MRI). The imaging contrast from the gold shell part of the magneto-plasmonic nanoparticles was also confirmed by X-ray computed tomography (CT). The transmigration study of the magneto-plasmonic nanoparticles using an in vitro blood-brain barrier (BBB) model proved enhanced transmigration efficiency without disrupting the integrity of the BBB, and showed potential to be used for brain diseases and neurological disorders.

Original languageEnglish (US)
Pages (from-to)764-773
Number of pages10
JournalNanoscale
Volume9
Issue number2
DOIs
StatePublished - Jan 14 2017

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ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Tomitaka, A., Arami, H., Raymond, A., Yndart, A., Kaushik, A., Jayant, R. D., Takemura, Y., Cai, Y., Toborek, M. J., & Nair, M. (2017). Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain. Nanoscale, 9(2), 764-773. https://doi.org/10.1039/c6nr07520g