Development of difference between red and white muscles in sensitivity to Ca2+ in the rabbit from embryo to adult

W. Glenn L. Kerrick, Diane Secrist, Robin Coby, Sylvia Lucas

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Ca2+ binding to troponin in red and white muscles does not entirely determine the sensitivity of these muscles to Ca2+, in spite of indications by previous biochemical experiments; that differences either in the troponin molecule or in light chains of myosin, or other unknown factors are responsible for the difference in sensitivity of calcium between the two types of muscles; and that molecular changes from embryo to adult change the Ca2+ sensitivity in red muscle. These data show the importance of using muscles of one type in experiments designed to show the exact molecular mechanism for activation of a contraction by Ca2+.

Original languageEnglish (US)
Pages (from-to)440-441
Number of pages2
JournalNature
Volume260
Issue number5550
DOIs
StatePublished - Dec 1 1976
Externally publishedYes

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